MRI1 and TRMT1

		MRI1	TRMT1
Description		methylthioribose-1-phosphate isomerase 1	tRNA methyltransferase 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cell Projection	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Isomerase Activity Identical Protein Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding TRNA (guanine) Methyltransferase Activity Transferase Activity Metal Ion Binding TRNA (guanine(26)-N2)-dimethyltransferase Activity
	Biological Process	Amino Acid Biosynthetic Process Methionine Biosynthetic Process L-methionine Salvage From Methylthioadenosine	TRNA N2-guanine Methylation TRNA Modification TRNA Processing Methylation
Pathways		Methionine salvage pathway	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Brain morphology (MOSTest) ( 32665545) Lymphocyte percentage of white cells ( 27863252) Mean platelet volume ( 32888494) Neutrophil percentage of white cells ( 27863252) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		4 interacting genes: ATF7IP COG6 PICK1 PLEKHF2	3 interacting genes: CFTR MAGEA11 TERF1
Entrez ID		84245	55621
HPRD ID		14548	08617
Ensembl ID		ENSG00000037757	ENSG00000104907
Uniprot IDs		Q9BV20	Q9NXH9
PDB IDs		4LDQ 4LDR	9DW6
Enriched GO Terms of Interacting Partners?		Trans-Golgi Network Membrane TRNA N2-guanine Methylation TRNA (guanine(26)-N2)-dimethyltransferase Activity	Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly S-methyl-5-thioribose-1-phosphate Isomerase Activity Positive Regulation Of Anion Channel Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Isomerase Activity Fibrillar Center Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Meiotic Telomere Clustering Ankyrin Repeat Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Localization To Perinuclear Region Of Cytoplasm FHF Complex L-methionine Salvage L-methionine Salvage From Methylthioadenosine Amelogenesis Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Microtubule Binding T-circle Formation Telomere Capping Methionine Biosynthetic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane HOPS Complex
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