LURAP1 and DOCK10

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LURAP1	DOCK10
Description		leucine rich adaptor protein 1	dedicator of cytokinesis 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Cell Projection Dendritic Spine Synapse Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Positive Regulation Of Cytokine Production Positive Regulation Of Canonical NF-kappaB Signal Transduction	B Cell Homeostasis Marginal Zone B Cell Differentiation Small GTPase-mediated Signal Transduction Regulation Of Cell Migration Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Dendritic Spine Morphogenesis Regulation Of Postsynapse Assembly
Pathways			CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Granulocyte percentage of myeloid white cells ( 27863252) IgE levels in asthmatics (D.p. specific) ( 23967269) LDL cholesterol levels in HIV infection ( 33109212) Mean platelet volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Response to bupropion and depression ( 27622933) Response to exercise (triglyceride level interaction) ( 26491034) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		21 interacting genes: ABI2 BLOC1S6 CCDC112 CCDC185 CSNK1D DOCK10 DTNB HAUS1 HGS HMG20A HUNK KRT3 PRPF31 SHFL SNAP29 TCEANC THAP7 TPM3 U2AF2 ZNF417 ZNF821	5 interacting genes: CCDC102B CFTR LURAP1 MAGEA11 RHOJ
Entrez ID		541468	55619
HPRD ID		18478	10919
Ensembl ID		ENSG00000171357	ENSG00000135905
Uniprot IDs		Q96LR2	A0A2R8YD85 Q96BY6
PDB IDs			6TKY 6TKZ 6TM1 7Q43
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Retina Vasculature Morphogenesis In Camera-type Eye Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Centriole-centriole Cohesion Golgi-associated Vesicle Membrane Cellular Response To Forskolin
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