PRIM2 and GTF3C6

		PRIM2	GTF3C6
Description		DNA primase subunit 2	general transcription factor IIIC subunit 6
Image
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm Nuclear Body
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding DNA/RNA Hybrid Binding	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Protein Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation	Transcription By RNA Polymerase III 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Chronotype ( 30696823) Coronary artery disease ( 33020668) Daytime nap ( 33568662) Myocardial infarction ( 33532862) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Systemic lupus erythematosus ( 28714469)	Refractive error ( 32231278)
Interacting Genes		7 interacting genes: KDM1A OGT POLA1 POLA2 PRIM1 RECK SUV39H1	2 interacting genes: APP SPATC1L
Entrez ID		5558	112495
HPRD ID		08900	12886
Ensembl ID		ENSG00000146143	ENSG00000155115
Uniprot IDs		P49643	Q969F1
PDB IDs		3L9Q 3Q36 4BPU 4BPW 4BPX 4RR2 5DQO 5EXR 5F0Q 5F0S 5I7M 6DHW 7OPL 7U5C 8B9D 8D0B 8D0K 8D96 8D9D 8QJ7 8VY3 9C8V	8CLK
Enriched GO Terms of Interacting Partners?		Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer DNA Replication Initiation Regulation Of Transcription By Glucose Macromolecule Biosynthetic Process Nucleoplasm DNA Replication Chromatin Binding Embryonic Forelimb Morphogenesis Developmental Maturation Forelimb Morphogenesis Macromolecule Metabolic Process Positive Regulation Of Stem Cell Proliferation RNA Metabolic Process Ligamentous Ossification Ribonucleotide Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Chromatin DNA Binding Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Nucleotidyltransferase Activity Limb Morphogenesis Regulation Of Multicellular Organismal Process Osteoblast Fate Commitment Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair ENoSc Complex Regulation Of Establishment Of Blood-brain Barrier Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Ossification Mitotic DNA Replication Initiation Nucleic Acid Metabolic Process Leading Strand Elongation Histone H3K9 Trimethyltransferase Activity Circadian Rhythm Protein Demethylase Activity RDNA Heterochromatin Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Cold-induced Thermogenesis Regulation Of Transcription From RNA Polymerase II Promoter By Glucose MRF Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of CAMP/PKA Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Alpha DNA Polymerase:primase Complex DNA/RNA Hybrid Binding Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway DNA Replication, Synthesis Of Primer Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?