PRIM1 and SLC11A2

		PRIM1	SLC11A2
Description		DNA primase subunit 1	solute carrier family 11 member 2
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Vacuole Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Endosome Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Brush Border Membrane Early Endosome Membrane Late Endosome Membrane Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Paraferritin Complex Extracellular Vesicle
	Molecular Function	Magnesium Ion Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleotide Binding Metal Ion Binding	Copper Ion Transmembrane Transporter Activity Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Protein Binding Calcium Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Nickel Cation Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity Symporter Activity Solute:proton Symporter Activity Inorganic Cation Transmembrane Transporter Activity Cadmium Ion Binding Metal Ion Transmembrane Transporter Activity Transition Metal Ion Transmembrane Transporter Activity Chromium Ion Transmembrane Transporter Activity Retromer Complex Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation	Response To Hypoxia Detection Of Oxygen Porphyrin-containing Compound Metabolic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Monoatomic Ion Transport Cobalt Ion Transport Copper Ion Transport Iron Ion Transport Manganese Ion Transport Intracellular Iron Ion Homeostasis Learning Or Memory Response To Iron Ion Nickel Cation Transport Vanadium Ion Transport Lead Ion Transport Metal Ion Transport Intracellular Manganese Ion Homeostasis Iron Import Into Cell Cellular Response To Oxidative Stress Iron Ion Transmembrane Transport Copper Ion Transmembrane Transport Nickel Cation Transmembrane Transport Dendrite Morphogenesis Erythrocyte Development Establishment Of Localization In Cell Transmembrane Transport Multicellular Organismal-level Iron Ion Homeostasis Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Zinc Ion Transmembrane Transport Proton Transmembrane Transport
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	Metal ion SLC transporters Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) Iron uptake and transport
Drugs			Ferric maltol
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Monocyte count ( 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 29403010)	Iron status biomarkers (ferritin levels) ( 33536631)
Interacting Genes		5 interacting genes: MDC1 MRPL38 OGT PRIM2 TP53	1 interacting genes: VPS35
Entrez ID		5557	4891
HPRD ID		08899	02750
Ensembl ID		ENSG00000198056	ENSG00000110911
Uniprot IDs		P49642	A0A0X8GKR4 F8W1P7 P49281
PDB IDs		4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V	5F0L 5F0M 5F0P 7BLO 7BLQ 9F6N 9F6O
Enriched GO Terms of Interacting Partners?		Nucleoplasm DNA-binding Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Nickel Cation Transmembrane Transporter Activity Nickel Cation Transport Nickel Cation Transmembrane Transport Solute:proton Symporter Activity Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Transition Metal Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity Macromolecule Biosynthetic Process Growth Plate Cartilage Chondrocyte Growth Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation Regulation Of Stem Cell Proliferation Positive Regulation Of DNA Recombination Isotype Switching To IgE Isotypes Transcription Coactivator Binding Mammary Gland Morphogenesis T Cell Lineage Commitment Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Helicase Activity Regulation Of Carbohydrate Catabolic Process Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Of Mitochondrion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Proteolysis Germ Cell Nucleus Cellular Response To Actinomycin D Mitophagy	Alpha DNA Polymerase:primase Complex Ribonucleotide Binding DNA Replication, Synthesis Of Primer Positive Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Protein Homooligomerization Mitochondrion-derived Vesicle Positive Regulation Of Wnt Protein Secretion Regulation Of Locomotion Involved In Locomotory Behavior Tubular Endosome Negative Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Dopamine Metabolic Process Retromer, Cargo-selective Complex Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Voluntary Musculoskeletal Movement Regulation Of Terminal Button Organization Regulation Of Dopamine Biosynthetic Process Mitochondrion To Lysosome Vesicle-mediated Transport Negative Regulation Of Protein Oligomerization D1 Dopamine Receptor Binding Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Regulation Of Lysosomal Protein Catabolic Process Regulation Of Dopamine Receptor Signaling Pathway Neurotransmitter Receptor Transport To Plasma Membrane Mitochondrial Fragmentation Involved In Apoptotic Process Dopaminergic Synapse Regulation Of Dendritic Spine Maintenance Musculoskeletal Movement Endosome To Plasma Membrane Protein Transport Protein Localization To Endosome Neurotransmitter Receptor Transport Transcytosis Regulation Of Dopamine Metabolic Process Positive Regulation Of Mitochondrial Fission Retromer Complex Regulation Of Presynapse Assembly Regulation Of Presynapse Organization DNA Replication Initiation Regulation Of Synapse Maturation Positive Regulation Of Behavior Regulation Of Mitochondrial Fission DNA-directed RNA Polymerase Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse DNA-directed RNA Polymerase Complex Mitochondrial Transport
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