SLC11A2

Description		solute carrier family 11 member 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Vacuole Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Endosome Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Brush Border Membrane Early Endosome Membrane Late Endosome Membrane Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Paraferritin Complex Extracellular Vesicle
	Molecular Function	Copper Ion Transmembrane Transporter Activity Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Protein Binding Calcium Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Nickel Cation Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity Symporter Activity Solute:proton Symporter Activity Inorganic Cation Transmembrane Transporter Activity Cadmium Ion Binding Metal Ion Transmembrane Transporter Activity Transition Metal Ion Transmembrane Transporter Activity Chromium Ion Transmembrane Transporter Activity Retromer Complex Binding
	Biological Process	Response To Hypoxia Detection Of Oxygen Porphyrin-containing Compound Metabolic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Monoatomic Ion Transport Cobalt Ion Transport Copper Ion Transport Iron Ion Transport Manganese Ion Transport Intracellular Iron Ion Homeostasis Learning Or Memory Response To Iron Ion Nickel Cation Transport Vanadium Ion Transport Lead Ion Transport Metal Ion Transport Intracellular Manganese Ion Homeostasis Iron Import Into Cell Cellular Response To Oxidative Stress Iron Ion Transmembrane Transport Copper Ion Transmembrane Transport Nickel Cation Transmembrane Transport Dendrite Morphogenesis Erythrocyte Development Establishment Of Localization In Cell Transmembrane Transport Multicellular Organismal-level Iron Ion Homeostasis Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Zinc Ion Transmembrane Transport Proton Transmembrane Transport
Pathways		Metal ion SLC transporters Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) Iron uptake and transport
Drugs		Ferric maltol
Diseases
GWAS		Iron status biomarkers (ferritin levels) ( 33536631)
Novel Interacting Genes		1 novel interacting genes: PRIM1
Interacting Genes		1 interacting genes: VPS35
Entrez ID		4891
HPRD ID		02750
Ensembl ID		ENSG00000110911
Uniprot IDs		A0A0X8GKR4 F8W1P7 P49281
PDB IDs		5F0L 5F0M 5F0P 7BLO 7BLQ 9F6N 9F6O
Enriched GO Terms of Interacting Partners?		Alpha DNA Polymerase:primase Complex Ribonucleotide Binding DNA Replication, Synthesis Of Primer Positive Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Protein Homooligomerization Mitochondrion-derived Vesicle Positive Regulation Of Wnt Protein Secretion Regulation Of Locomotion Involved In Locomotory Behavior Tubular Endosome Negative Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Dopamine Metabolic Process Retromer, Cargo-selective Complex Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Voluntary Musculoskeletal Movement Regulation Of Terminal Button Organization Regulation Of Dopamine Biosynthetic Process Mitochondrion To Lysosome Vesicle-mediated Transport Negative Regulation Of Protein Oligomerization D1 Dopamine Receptor Binding Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Regulation Of Lysosomal Protein Catabolic Process Regulation Of Dopamine Receptor Signaling Pathway Neurotransmitter Receptor Transport To Plasma Membrane Mitochondrial Fragmentation Involved In Apoptotic Process Dopaminergic Synapse Regulation Of Dendritic Spine Maintenance Musculoskeletal Movement Endosome To Plasma Membrane Protein Transport Protein Localization To Endosome Neurotransmitter Receptor Transport Transcytosis Regulation Of Dopamine Metabolic Process Positive Regulation Of Mitochondrial Fission Retromer Complex Regulation Of Presynapse Assembly Regulation Of Presynapse Organization DNA Replication Initiation Regulation Of Synapse Maturation Positive Regulation Of Behavior Regulation Of Mitochondrial Fission DNA-directed RNA Polymerase Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse DNA-directed RNA Polymerase Complex Mitochondrial Transport
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