TMEM140 and KCNJ8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM140	KCNJ8
Description		transmembrane protein 140	potassium inwardly rectifying channel subfamily J member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Inward Rectifying Potassium Channel Membrane Myofibril Potassium Ion-transporting ATPase Complex Protein-containing Complex Monoatomic Ion Channel Complex Sarcolemma Presynaptic Active Zone Membrane Presynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Inward Rectifier Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process		Action Potential Blood Vessel Development Response To Hypoxia Microglial Cell Activation Kidney Development Vasculature Development Regulation Of Heart Rate Adaptive Immune Response Response To Ischemia Heart Morphogenesis Ventricular Cardiac Muscle Tissue Development Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Response To Stress Inflammatory Response Heart Development Regulation Of Blood Pressure Cell Population Proliferation Determination Of Adult Lifespan Protein Secretion Response To Xenobiotic Stimulus Gene Expression Fatty Acid Transport Transmission Of Nerve Impulse Establishment Of Cell Polarity Response To Lipopolysaccharide Response To Insulin Response To ATP Response To Cytokine Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress P38MAPK Cascade Vasodilation Response To Exogenous DsRNA NLRP3 Inflammasome Complex Assembly Fat Cell Differentiation Fibroblast Proliferation Nervous System Process Neuromuscular Process Synaptic Assembly At Neuromuscular Junction Defense Response To Virus Cardiac Pacemaker Cell Differentiation Atrioventricular Node Cell Differentiation Coronary Vasculature Development Glutamate Secretion, Neurotransmission CAMKK-AMPK Signaling Cascade Calcium Ion Transmembrane Transport Potassium Ion Transmembrane Transport Circulatory System Development Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Presynaptic Membrane Potential Reactive Gliosis Transport Across Blood-brain Barrier Response To Resveratrol Potassium Ion Import Across Plasma Membrane
Pathways			ATP sensitive Potassium channels
Drugs			Ritodrine Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine Butamben
Diseases
GWAS			Birth weight ( 31043758)
Interacting Genes		51 interacting genes: APH1A AQP6 ASGR2 CD22 CD53 CD79A CGRRF1 CLDN5 CLDN7 CLEC17A CLRN1 CREB3 EBP ERGIC3 FAM209A FAM210B FCER1G FNDC9 GOLM1 GPR152 GPR42 HHLA2 HSD17B13 IFNGR2 KCNJ8 KRTAP10-8 LMNA LY6E MFF MGST3 MILR1 MS4A3 MSMO1 PDZK1IP1 PSCA RMDN3 SCN3B SHISAL1 SIT1 SLC39A9 SPACA1 STOM SYNE4 TEX29 TMEM182 TMEM205 TMEM207 TMEM9 TMX2 TSPAN12 TSPO2	7 interacting genes: ABCC8 ABCC9 EMD KCNJ11 KCNJ2 TMEM140 TMEM54
Entrez ID		55281	3764
HPRD ID		07723	02962
Ensembl ID		ENSG00000146859	ENSG00000121361
Uniprot IDs		Q9NV12	Q15842
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane Identical Protein Binding Fucose Binding	Inward Rectifying Potassium Channel ATP-activated Inward Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Inorganic Cation Import Across Plasma Membrane Action Potential Sulfonylurea Receptor Activity Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Potassium Ion-transporting ATPase Complex Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Transmembrane Transporter Binding Inward Rectifier Potassium Channel Activity Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To ATP System Process Positive Regulation Of Potassium Ion Transport Inorganic Ion Transmembrane Transport Regulation Of Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of Insulin Secretion ABC-type Transporter Activity T-tubule Negative Regulation Of Peptide Secretion Regulation Of Monoatomic Ion Transmembrane Transport Cardiac Conduction Response To Xenobiotic Stimulus Monoatomic Ion Transport Regulation Of Metal Ion Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Hormone Secretion TMEM240-body Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Negative Regulation Of Protein Secretion Positive Regulation Of Uterine Smooth Muscle Relaxation Negative Regulation Of Neuroblast Migration Potassium Channel Activity Regulation Of Protein Transport Transmembrane Transport Relaxation Of Skeletal Muscle Sarcolemma Regulation Of Establishment Of Protein Localization Regulation Of System Process
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