MACO1 and LCE3D

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		MACO1	LCE3D
Description		macoilin 1	late cornified envelope 3D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Axon Rough Endoplasmic Reticulum Membrane Nuclear Membrane Cell Projection Neuron Projection Neuron Projection Terminus Synapse	Cytosol
	Molecular Function	Molecular_function Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Chemotaxis Brain Development Neuronal Signal Transduction	Epidermis Development Keratinization
Pathways		RHOA GTPase cycle RHOC GTPase cycle	Formation of the cornified envelope
Drugs
Diseases
GWAS		LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Psoriasis ( 19169255 20953190 23143594 25854761)
Interacting Genes		26 interacting genes: CRCT1 HOXA1 KRTAP5-2 KRTAP5-7 LCE1A LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3D LCE3E LCE5A LINGO1 MEI4 MEOX2 NBPF19 NOTCH2NLA NR4A3 POTEB3 SMAD9 SMCP SRPK2 TMEM190 ZNF655	69 interacting genes: ADAMTSL4 ALPP CCN3 CHIC2 CYP21A2 CYSRT1 EFEMP1 EFEMP2 FBLN2 HOXA1 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2A LCE2B LCE2C LCE2D MACO1 MDFI NBPF19 NOTCH2NLA PCSK5 RGS17 RGS20 SDC3 SPRY1 SPRY3 SRPK1 SRPK2 TENM4 TGFB1 TRIM42 TSPAN4 VWC2 VWC2L
Entrez ID		55219	84648
HPRD ID		13340	17263
Ensembl ID		ENSG00000204178	ENSG00000163202
Uniprot IDs		Q8N5G2	Q9BYE3
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Tissue Development Developmental Process	Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Cytosol Keratinization Protein Binding Extracellular Matrix Interstitial Matrix
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