ALKBH5 and USP36

Number of citations of the paper that reports this interaction (PubMedID 36239338)
40

Data Source:
BioGRID (enzymatic study)

		ALKBH5	USP36
Description		alkB homolog 5, RNA demethylase	ubiquitin specific peptidase 36
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Cytosol Nuclear Speck Paraspeckles	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Oxidative RNA Demethylase Activity Metal Ion Binding Dioxygenase Activity Molecular Condensate Scaffold Activity MRNA N6-methyladenosine Dioxygenase Activity	RNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Transferase Activity Hydrolase Activity Histone H2B Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Response To Hypoxia MRNA Processing Regulation Of Translation Spermatogenesis Regulation Of MRNA Export From Nucleus Cell Differentiation Regulation Of MRNA Stability Gamma-delta T Cell Proliferation Regulation Of MRNA Processing MRNA Destabilization Membraneless Organelle Assembly	Chromatin Organization Chromatin Remodeling Proteolysis Nucleolus Organization Negative Regulation Of Macroautophagy Protein Deubiquitination Regulation Of Protein Stability Regulation Of Apoptotic Process Protein Stabilization Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of RRNA Processing
Pathways		Reversal of alkylation damage by DNA dioxygenases
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Atrial fibrillation ( 30061737) Diverticular disease ( 30177863) Heel bone mineral density ( 30598549) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418 31928498)
Interacting Genes		4 interacting genes: CEBPA CSNK2A1 OGT USP36	19 interacting genes: ALKBH5 EXOSC10 H2BC3 MIR128-1 MIR138-2 MIR15B MIR16-1 MIR17 MIR19B2 MIR21 MIR29A MIR29C MIR34B MIR7-1 MYC PRIMPOL PTBP1 SUMO2 UBE2I
Entrez ID		54890	57602
HPRD ID		08621	07164
Ensembl ID		ENSG00000091542	ENSG00000055483
Uniprot IDs		Q6P6C2	A0A075B784 Q9P275
PDB IDs		4NJ4 4NRM 4NRO 4NRP 4NRQ 4O61 4O7X 4OCT 7V4G 7WKV 7WL0	8BS3 8BS9
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Sin3-type Complex Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Chromatin DNA Binding Protein Localization To Vacuole RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Organelle Organization Response To Nutrient Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Macroautophagy CHOP-C/EBP Complex Negative Regulation Of Metabolic Process Negative Regulation Of Translation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Proteolysis Carbohydrate Homeostasis Glucose Homeostasis Positive Regulation Of Protein Catabolic Process White Fat Cell Proliferation Regulation Of Macroautophagy Histone H2B Deubiquitinase Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Protein Stabilization Positive Regulation Of Aggrephagy Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Rhythmic Process Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Nucleolus Organization Response To Phenylpropanoid	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Translation Positive Regulation Of Connective Tissue Replacement Extracellular Vesicle Regulation Of Connective Tissue Replacement Regulation Of Gene Expression Positive Regulation Of Tissue Remodeling Regulation Of Macromolecule Biosynthetic Process Regulation Of Endothelial Cell Proliferation Negative Regulation Of Amyloid-beta Formation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Developmental Process Regulation Of Amide Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition
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