ALKBH5

Description		alkB homolog 5, RNA demethylase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Cytosol Nuclear Speck Paraspeckles
	Molecular Function	RNA Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Oxidative RNA Demethylase Activity Metal Ion Binding Dioxygenase Activity Molecular Condensate Scaffold Activity MRNA N6-methyladenosine Dioxygenase Activity
	Biological Process	Response To Hypoxia MRNA Processing Regulation Of Translation Spermatogenesis Regulation Of MRNA Export From Nucleus Cell Differentiation Regulation Of MRNA Stability Gamma-delta T Cell Proliferation Regulation Of MRNA Processing MRNA Destabilization Membraneless Organelle Assembly
Pathways		Reversal of alkylation damage by DNA dioxygenases
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: CEBPA CSNK2A1 OGT USP36
Entrez ID		54890
HPRD ID		08621
Ensembl ID		ENSG00000091542
Uniprot IDs		Q6P6C2
PDB IDs		4NJ4 4NRM 4NRO 4NRP 4NRQ 4O61 4O7X 4OCT 7V4G 7WKV 7WL0
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Sin3-type Complex Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Chromatin DNA Binding Protein Localization To Vacuole RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Organelle Organization Response To Nutrient Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Macroautophagy CHOP-C/EBP Complex Negative Regulation Of Metabolic Process Negative Regulation Of Translation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Proteolysis Carbohydrate Homeostasis Glucose Homeostasis Positive Regulation Of Protein Catabolic Process White Fat Cell Proliferation Regulation Of Macroautophagy Histone H2B Deubiquitinase Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Protein Stabilization Positive Regulation Of Aggrephagy Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Rhythmic Process Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Nucleolus Organization Response To Phenylpropanoid
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