VPS13C and RAB8B

		VPS13C	RAB8B
Description		vacuolar protein sorting 13 homolog C	RAB8B, member RAS oncogene family
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Membrane Late Endosome Membrane Dense Core Granule Membrane Extracellular Exosome	Endosome Peroxisomal Membrane Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle Phagocytic Vesicle Membrane Cytoplasmic Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Cell Tip Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Presynapse
	Molecular Function		Nucleotide Binding GTPase Activity Signaling Receptor Binding Protein Binding GTP Binding Hydrolase Activity GDP Binding TPR Domain Binding Metal Ion Binding
	Biological Process	Protein Targeting To Vacuole Lipid Transport Golgi To Endosome Transport Mitochondrion Organization Response To Insulin Protein Retention In Golgi Apparatus Negative Regulation Of Type 2 Mitophagy	Exocytosis Protein Transport Antigen Processing And Presentation Positive Regulation Of Cell Projection Organization Endocytic Recycling Protein Import Into Peroxisome Membrane Positive Regulation Of Corticotropin Secretion Cilium Assembly Cell-substrate Junction Organization
Pathways			TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs			Phosphoaminophosphonic acid guanylate ester Guanosine-5'-Diphosphate
Diseases
GWAS		Asthma ( 29273806) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Body mass index ( 28892062) Breast size ( 27182965) Cataracts ( 34127677) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Insular cortex volume ( 31530798) Intraocular pressure ( 29785010 31959993 30054594) Parkinson's disease ( 28892059 25064009) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Proinsulin levels ( 21873549) Schizophrenia ( 29483656 28991256) Triglyceride levels ( 32203549) Tuberculosis susceptibility in HIV infection ( 26942285) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857)	Refractive error ( 32231278) Serum metabolite levels ( 23093944) Social communication problems ( 24564958)
Interacting Genes		2 interacting genes: SNCA TMEM132D	7 interacting genes: APP CDH1 RAB3IP RALA TUBA4A TUBB VIM
Entrez ID		54832	51762
HPRD ID		12323	11476
Ensembl ID		ENSG00000129003	ENSG00000166128
Uniprot IDs		Q709C8	Q92930
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Synaptic Vesicle Negative Regulation Of Dopamine Metabolic Process Presynapse Negative Regulation Of Serotonin Uptake Regulation Of Chaperone-mediated Autophagy Transporter Regulator Activity Exocytosis Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Catecholamine Metabolic Process Response To Iron(II) Ion Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake Positive Regulation Of Secretion By Cell Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Protein Import Into Peroxisome Membrane Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion TPR Domain Binding Cell Tip Pyruvate Catabolic Process L-lactate Dehydrogenase (NAD+) Activity Oxidoreductase Complex Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Secretion Cuprous Ion Binding Dopamine Biosynthetic Process Negative Regulation Of Cellular Respiration Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Positive Regulation Of Neurotransmitter Secretion Regulation Of SNARE Complex Assembly Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport	Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Extracellular Exosome Cellular Localization Nuclear Envelope Lumen GTPase Activating Protein Binding Structural Constituent Of Cytoskeleton Negative Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Plasma Membrane Bounded Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cell Development GTP Binding Regulation Of Receptor Internalization Cell Body Acetylcholine Receptor Activator Activity Lipoprotein Particle Cell Projection Organization Positive Regulation Of Protein Import Edg-2 Lysophosphatidic Acid Receptor Binding Dense Core Granule Membrane Negative Regulation Of Type 2 Mitophagy Ciliary Basal Body-plasma Membrane Docking PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Neuron Projection Development Post-Golgi Vesicle-mediated Transport Localization Within Membrane Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Response To External Biotic Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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