VPS13C

Description		vacuolar protein sorting 13 homolog C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Membrane Late Endosome Membrane Dense Core Granule Membrane Extracellular Exosome
	Molecular Function
	Biological Process	Protein Targeting To Vacuole Lipid Transport Golgi To Endosome Transport Mitochondrion Organization Response To Insulin Protein Retention In Golgi Apparatus Negative Regulation Of Type 2 Mitophagy
Pathways
Drugs
Diseases
GWAS		Asthma ( 29273806) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Body mass index ( 28892062) Breast size ( 27182965) Cataracts ( 34127677) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Insular cortex volume ( 31530798) Intraocular pressure ( 29785010 31959993 30054594) Parkinson's disease ( 28892059 25064009) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Proinsulin levels ( 21873549) Schizophrenia ( 29483656 28991256) Triglyceride levels ( 32203549) Tuberculosis susceptibility in HIV infection ( 26942285) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857)
Novel Interacting Genes		2 novel interacting genes: LDHAL6B RAB8B
Interacting Genes		2 interacting genes: SNCA TMEM132D
Entrez ID		54832
HPRD ID		12323
Ensembl ID		ENSG00000129003
Uniprot IDs		Q709C8
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Synaptic Vesicle Negative Regulation Of Dopamine Metabolic Process Presynapse Negative Regulation Of Serotonin Uptake Regulation Of Chaperone-mediated Autophagy Transporter Regulator Activity Exocytosis Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Catecholamine Metabolic Process Response To Iron(II) Ion Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake Positive Regulation Of Secretion By Cell Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Protein Import Into Peroxisome Membrane Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion TPR Domain Binding Cell Tip Pyruvate Catabolic Process L-lactate Dehydrogenase (NAD+) Activity Oxidoreductase Complex Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Secretion Cuprous Ion Binding Dopamine Biosynthetic Process Negative Regulation Of Cellular Respiration Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Positive Regulation Of Neurotransmitter Secretion Regulation Of SNARE Complex Assembly Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport
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