ZRANB1 and UBE2S

Number of citations of the paper that reports this interaction (PMID 20622874)
46

Data Source:
BioGRID (enzymatic study)

		ZRANB1	UBE2S
Gene Name		zinc finger, RAN-binding domain containing 1	ubiquitin-conjugating enzyme E2S
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Anaphase-promoting Complex Cytoplasm
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding K63-linked Polyubiquitin Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cytoskeleton Organization Wnt Signaling Pathway Cell Migration Regulation Of Cell Morphogenesis Positive Regulation Of Wnt Signaling Pathway Protein K29-linked Deubiquitination Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Deubiquitination	Cellular Protein Modification Process Exit From Mitosis Free Ubiquitin Chain Polymerization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Activation Of Anaphase-promoting Complex Activity Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CORO7 TRAF6 UBC UBE2S	29 interactors: ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CYLD FZR1 OTUB1 OTUD7B RBCK1 STAMBP UBA1 UBA6 UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1
Entrez ID		54764	27338
HPRD ID		11738	15603
Ensembl ID		ENSG00000019995	ENSG00000108106
Uniprot IDs		Q9UGI0	Q16763
PDB IDs		3ZRH	1ZDN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Ubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Transferase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Ubiquitination Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Protein Modification By Small Protein Conjugation JNK Cascade Regulation Of Ubiquitin-protein Transferase Activity Protein Polymerization Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Protein Modification Process Protein Complex Assembly Free Ubiquitin Chain Polymerization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Endosomal Transport Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway	Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein K11-linked Ubiquitination Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Protein Modification Process Positive Regulation Of Ligase Activity Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Assembly Checkpoint Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Spindle Assembly Checkpoint Regulation Of Protein Ubiquitination Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Spindle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Chromosome Segregation Protein Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Spindle Checkpoint Negative Regulation Of Chromosome Organization Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Protein Modification By Small Protein Removal Protein Ubiquitination Negative Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih hif1an interacted interesting mib mib2 mind notch protease screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish	arising cluster clusters coexpressed coexpression conjugating coregulated endpoints example examples friendly glados guilt http ie kcnk5 messenger modules online outputs potassium powerful subfamily ucd uncovered user weighted wgcna
Tagcloud (Difference) ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih hif1an interacted interesting mib mib2 mind notch protease screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish	arising cluster clusters coexpressed coexpression conjugating coregulated endpoints example examples friendly glados guilt http ie kcnk5 messenger modules online outputs potassium powerful subfamily ucd uncovered user weighted wgcna
Tagcloud (Intersection) ?