NUTM2F and PRPF18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NUTM2F	PRPF18
Description		NUT family member 2F	pre-mRNA processing factor 18
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex
	Molecular Function		Protein Binding
	Biological Process		Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28892062) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) Craniofacial microsomia ( 26853712) Lupus nephritis in systemic lupus erythematosus ( 24925725) Post bronchodilator FEV1/FVC ratio ( 26634245) Skin pigmentation ( 28300201)
Interacting Genes		20 interacting genes: AIRIM ANKS1A ATXN1L FADD GRB2 HGS LENG8 MORN4 NCK1 NCK2 NFYC OSTF1 PRPF18 RAD23A RBM47 SH3GL1 SH3RF1 VPS37C ZMYND10 ZNF148	81 interacting genes: AGTRAP AMOTL2 AP2M1 ASCC2 BEGAIN BICD2 BLZF1 CADPS CALCOCO2 CARD10 CARD9 CBY2 CCDC102B CCDC136 CCDC150 CCDC57 CCNC CDR2 CEP70 CSRNP1 DRC4 DVL3 EFHC2 EVI5L FERMT3 FSD2 GCC1 GOLGA2 GOLGA6L9 GPBP1 GRIPAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKBKG IKZF1 KANK2 KCTD7 KIFC3 KRT31 KRT34 KRT35 KRT39 KRT40 LDOC1 LZTS1 LZTS2 MCC MDFI MEOX2 MTUS2 NACC1 NECAB2 NINL NUTM1 NUTM2F OSBPL3 PDE9A PFDN5 PIBF1 PICK1 PLEKHG4 PNMA1 PPIH PRKAR1B RHOU RINT1 SCHIP1 SPRED1 STX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TSNAX TSNAXIP1 UBXN11 ZNF526 ZNF639
Entrez ID		54754	8559
HPRD ID		19318	05407
Ensembl ID		ENSG00000130950	ENSG00000165630
Uniprot IDs		A1L443	Q99633
PDB IDs			2DK4
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Vesicle Membrane Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Actin Filament Polymerization Ephrin Receptor Signaling Pathway Positive Regulation Of Translation In Response To Stress Signal Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of T Cell Proliferation Regulation Of Translational Initiation In Response To Stress Regulation Of T Cell Activation Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Signaling Adaptor Activity Positive Regulation Of Protein Polymerization Regulation Of PERK-mediated Unfolded Protein Response Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Cytoskeletal Anchor Activity Positive Regulation Of T Cell Proliferation Regulation Of Translation In Response To Stress Regulation Of Leukocyte Proliferation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway T Cell Activation Regulation Of Actin Filament Polymerization Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Activation Signaling Receptor Complex Adaptor Activity Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Multivesicular Body Organization Multivesicular Body Assembly Lamellipodium Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Late Endosome To Vacuole Transport Positive Regulation Of Supramolecular Fiber Organization Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation	Protein Binding Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament Organization Microtubule Identical Protein Binding Cytoskeleton Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process A2A Adenosine Receptor Binding Organelle Organization CBM Complex Cytosol Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
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