PRPF18 and DRC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRPF18	DRC4
Description		pre-mRNA processing factor 18	dynein regulatory complex subunit 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex	Extracellular Region Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection 9+2 Motile Cilium
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding Small GTPase Binding
	Biological Process	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA Processing RNA Splicing	Microtubule Cytoskeleton Organization Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Brain Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Flagellated Sperm Motility Axoneme Assembly Positive Regulation Of Smoothened Signaling Pathway Cell Motility Establishment Of Localization In Cell Cilium Movement Involved In Cell Motility Positive Regulation Of Protein Localization To Cilium
Pathways		mRNA Splicing - Major Pathway	Activation of SMO
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) Craniofacial microsomia ( 26853712) Lupus nephritis in systemic lupus erythematosus ( 24925725) Post bronchodilator FEV1/FVC ratio ( 26634245) Skin pigmentation ( 28300201)
Interacting Genes		81 interacting genes: AGTRAP AMOTL2 AP2M1 ASCC2 BEGAIN BICD2 BLZF1 CADPS CALCOCO2 CARD10 CARD9 CBY2 CCDC102B CCDC136 CCDC150 CCDC57 CCNC CDR2 CEP70 CSRNP1 DRC4 DVL3 EFHC2 EVI5L FERMT3 FSD2 GCC1 GOLGA2 GOLGA6L9 GPBP1 GRIPAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKBKG IKZF1 KANK2 KCTD7 KIFC3 KRT31 KRT34 KRT35 KRT39 KRT40 LDOC1 LZTS1 LZTS2 MCC MDFI MEOX2 MTUS2 NACC1 NECAB2 NINL NUTM1 NUTM2F OSBPL3 PDE9A PFDN5 PIBF1 PICK1 PLEKHG4 PNMA1 PPIH PRKAR1B RHOU RINT1 SCHIP1 SPRED1 STX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TSNAX TSNAXIP1 UBXN11 ZNF526 ZNF639	110 interacting genes: ARL6IP1 BCAR3 BORCS6 BYSL C1orf35 CARD10 CARD9 CBFA2T3 CCDC125 CCDC146 CCDC6 CCHCR1 CCNG1 CDC37 CDR2 CEP70 CFAP53 CINP CKS1B COG6 CPSF7 CRYBB1 CT45A1 CWF19L2 CYSRT1 DAXX DDX17 DISC1 DMAP1 EAF1 EHHADH EIF1AD ERCC1 EVI5L FAM161A FAM161B FHL2 GADD45GIP1 GCC1 GEM GOLGA2 GPRASP3 GRIPAP1 GSTA4 HEXIM2 HOMER3 HOMEZ HOXA1 HSF2BP IGFBP6 KDM1A KRT14 KRT15 KRT16 L3MBTL2 L3MBTL3 LASP1 LHX3 LMO1 LMO2 LZTS1 MAD1L1 MFAP1 MID2 MRFAP1L1 NDOR1 NKAPD1 PLK4 PNKP PNMA5 POLR1C POTEB3 PPFIA1 PRDM14 PRMT5 PRPF18 RALBP1 RBAK RINT1 RUBCN SCNM1 SKIL SORBS3 SP7 SPATA18 SPG21 STAC3 TCEA2 THAP1 TNFAIP3 TRAF2 TRAF5 TRIM41 TRIM54 TSFM TSGA10IP TXLNA TXLNB USHBP1 YES1 YJU2 ZBTB22 ZBTB26 ZBTB39 ZNF212 ZNF250 ZNF572 ZNF620 ZNF629 ZNF792
Entrez ID		8559	2622
HPRD ID		05407	05533
Ensembl ID		ENSG00000165630	ENSG00000141013
Uniprot IDs		Q99633	A0A087WZT7 A0A384MR00 B7Z1U9 O95995
PDB IDs		2DK4	8J07
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament Organization Microtubule Identical Protein Binding Cytoskeleton Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process A2A Adenosine Receptor Binding Organelle Organization CBM Complex Cytosol Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Identical Protein Binding Protein Binding Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
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