RAB39A and RAB3GAP1

Number of citations of the paper that reports this interaction (PubMedID 16923123)
0

Data Source:
BioGRID (two hybrid)

		RAB39A	RAB3GAP1
Description		RAB39A, member RAS oncogene family	RAB3 GTPase activating protein catalytic subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Cytosol Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Phagocytic Vesicle Autolysosome Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Lipid Droplet Cytosol Protein-containing Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Postsynapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Autophagy Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Autophagosome-lysosome Fusion Phagosome Acidification Phagosome-lysosome Fusion	Brain Development Hypothalamus Development Rab Protein Signal Transduction Lipid Droplet Organization Camera-type Eye Development Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly
Pathways		Intra-Golgi traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Warburg micro syndrome Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS			Body mass index ( 25673413) Cholesterol, total ( 20686565 24097068 25961943) Corneal structure ( 21979947) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Sudden cardiac arrest in coronary artery disease ( 23593153)
Interacting Genes		5 interacting genes: APP BLZF1 GOLGA2 GORASP2 RAB3GAP1	8 interacting genes: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7
Entrez ID		54734	22930
HPRD ID		11470	16002
Ensembl ID		ENSG00000179331	ENSG00000115839
Uniprot IDs		Q14964	A0A8J9AUI2 B9A6J2 Q15042
PDB IDs			8VYB
Enriched GO Terms of Interacting Partners?		Cis-Golgi Network Cellular Localization Golgi Organization Golgi Apparatus Establishment Of Protein Localization Establishment Of Protein Localization To Membrane Regulation Of Neuronal Synaptic Plasticity Establishment Of Protein Localization To Plasma Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Vesicle-mediated Transport Organelle Organization Protein Tetramerization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Synaptic Transmission Lipoprotein Particle Endoplasmic Reticulum Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Membrane Localization Within Membrane Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Protein Glycosylation Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission	Regulation Of Autophagosome Assembly Regulation Of Vacuole Organization Autolysosome Membrane Regulation Of Autophagy Negative Regulation Of Autophagosome Assembly Rab Protein Signal Transduction Protein Transport Regulation Of Macroautophagy Establishment Of Protein Localization Negative Regulation Of Macroautophagy Regulation Of Organelle Assembly Autophagy Cytoplasmic Vesicle GTPase Activity Intracellular Protein Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion GTP Binding G Protein Activity Phagocytic Vesicle Membrane Phagocytic Vesicle Negative Regulation Of Autophagy Vesicle-mediated Transport Regulation Of Organelle Organization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Intracellular Protein Transport Positive Regulation Of Protein Lipidation Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Protein Lipidation Phagosome Acidification Regulation Of Organelle Transport Along Microtubule Axon Guidance Neuron Projection Guidance Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Lipoprotein Metabolic Process Small GTPase-mediated Signal Transduction Autophagosome-lysosome Fusion Phagosome-lysosome Fusion Small GTPase Binding Myosin V Binding Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle Size Vesicle Organization Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Autophagosome Assembly
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