LCE2C and EFNA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE2C	EFNA3
Description		late cornified envelope 2C	ephrin A3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Epidermis Development Keratinization	Cell-cell Signaling Axon Guidance Negative Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Formation of the cornified envelope	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Optic disc size ( 31809533) Prostate cancer ( 23535732) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin excretion ( 30220432)
Interacting Genes		87 interacting genes: ADAMTSL4 ALPP C1orf94 CATSPER1 CCDC125 CHIC2 CRCT1 CREB5 CYP21A2 CYSRT1 EFEMP1 EFEMP2 EFNA3 FAM221B HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2D LCE3A LCE3B LCE3D LCE4A LCE5A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 OTX1 PCSK5 PIAS2 POU4F2 PTPMT1 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRY1 TAP1 TGFB1 TM7SF2 TRIM42 UBE2I VASN VWC2 XAGE3	11 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 KRTAP1-1 KRTAP10-3 LCE2C MEOX2 NOTCH2NLA PRSS23
Entrez ID		353140	1944
HPRD ID		13972	03225
Ensembl ID		ENSG00000187180	ENSG00000143590
Uniprot IDs		Q5TA81	P52797
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding	Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway Transmembrane-ephrin Receptor Activity Protein Tyrosine Kinase Activity Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Regulation Of GTPase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Nephric Duct Morphogenesis Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Axonal Fasciculation Neuron Projection Fasciculation Ephrin Receptor Binding Dendrite Neuron Projection Development Growth Factor Binding Regulation Of Catalytic Activity Neuron Recognition Notochord Cell Development DH Domain Binding Regulation Of Cell Junction Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Projection Organization Positive Regulation Of Protein Localization To Plasma Membrane Tube Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Morphogenesis Of An Epithelium Axial Mesoderm Formation Neuromuscular Junction Positive Regulation Of Protein Localization To Membrane ATP Binding Regulation Of Cell Adhesion Keratin Filament Negative Regulation Of Lymphangiogenesis Notochord Formation Schaffer Collateral - CA1 Synapse Plasma Membrane Bounded Cell Projection Organization Postsynaptic Density Membrane Tissue Morphogenesis Epithelial Tube Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Blood Vessel Endothelial Cell Migration
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?