EPB41L4B and HSP90B1

		EPB41L4B	HSP90B1
Description		erythrocyte membrane protein band 4.1 like 4B	heat shock protein 90 beta family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Apical Part Of Cell Anchoring Junction	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Sarcoplasmic Reticulum Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Plasma Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Cytoskeletal Protein Binding	Nucleotide Binding RNA Binding Protein Phosphatase Inhibitor Activity Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Positive Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Actomyosin Structure Organization Wound Healing Positive Regulation Of Cell Adhesion Positive Regulation Of Keratinocyte Migration	Response To Hypoxia Protein Folding Protein Transport Positive Regulation Of Wnt Signaling Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Apoptotic Process Sequestering Of Calcium Ion Cellular Response To Manganese Ion Cellular Response To ATP Protein Localization To Plasma Membrane
Pathways			Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS		Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Body mass index ( 25673413 28892062) Degraded stimulus continuous performance test score ( 31596458) High density lipoprotein cholesterol levels ( 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Low vWF levels ( 26486471) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Umami taste perception in obesity with metabolic syndrome ( 31005965)	Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		2 interacting genes: LAMC3 SRPK2	40 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 GRIK1 HSPA13 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 NR5A2 OGT POLR2E PTEN PTPN11 PVT1 RNF10 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A
Entrez ID		54566	7184
HPRD ID		09940	01860
Ensembl ID		ENSG00000095203	ENSG00000166598
Uniprot IDs		Q59GC2 Q9H329 Q9NX84	P14625 V9HWP2
PDB IDs			4NH9 7ULL
Enriched GO Terms of Interacting Partners?		Nuclear Body Organization R-loop Processing Nuclear Speck Organization Sequestering Of Calcium Ion Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Sarcoplasmic Reticulum Lumen Cellular Response To ATP Endoplasmic Reticulum Chaperone Complex Endocytic Vesicle Lumen Response To Manganese Ion Positive Regulation Of Toll-like Receptor Signaling Pathway Sperm Plasma Membrane Protein Folding In Endoplasmic Reticulum Cellular Response To Manganese Ion Astrocyte Development Smooth Endoplasmic Reticulum	Receptor Complex Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Negative Regulation Of Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Heart Development Detection Of Molecule Of Bacterial Origin Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Lipoprotein Transport Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Catabolic Process Regulation Of Interferon-beta Production Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Cellular Response To Actinomycin D Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Negative Regulation Of Cell Differentiation Regulation Of Signal Transduction Response To Actinomycin D Detection Of Bacterial Lipoprotein Regulation Of Proteolysis ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding
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