POLR2J and POLR2K

Number of citations of the paper that reports this interaction (PMID 9201987)
16

Data Source:
BioGRID (pull down)

		POLR2J	POLR2K
Gene Name		polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa	polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex DNA-directed RNA Polymerase III Complex DNA-directed RNA Polymerase I Complex Cytosol
	Molecular Function	RNA Polymerase II Activity DNA Binding DNA-directed RNA Polymerase Activity Protein Binding LRR Domain Binding Protein Dimerization Activity	RNA Polymerase I Activity RNA Polymerase II Activity RNA Polymerase III Activity DNA Binding Zinc Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription RNA Splicing Gene Expression Viral Process Positive Regulation Of Type I Interferon Production PiRNA Metabolic Process Somatic Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation Abortive elongation of HIV-1 transcript in the absence of Tat RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Regulatory RNA pathways Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER Influenza Life Cycle RNA Polymerase III Transcription Termination HIV elongation arrest and recovery NoRC negatively regulates rRNA expression Influenza Viral RNA Transcription and Replication RNA Polymerase III Chain Elongation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle RNA Polymerase III Transcription Initiation From Type 2 Promoter Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Abortive And Retractive Initiation Transcription of the HIV genome Nucleotide Excision Repair PIWI-interacting RNA (piRNA) biogenesis mRNA Splicing RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Innate Immune System RNA Polymerase III Transcription Initiation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Cytosolic sensors of pathogen-associated DNA Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Pausing and recovery of HIV elongation Formation of the HIV-1 Early Elongation Complex Viral Messenger RNA Synthesis RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AATF BAG6 CD14 LARP1B POLR1C POLR2C POLR2K SATB1	12 interactors: APP BRCA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2J SMYD3
Entrez ID		5439	5440
HPRD ID		16038	05826
Ensembl ID		ENSG00000005075	ENSG00000147669
Uniprot IDs		P52435	P53803
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription, Elongation Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter PiRNA Metabolic Process 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus Response To Stress Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription From RNA Polymerase III Promoter Apoptotic Process Programmed Cell Death Immune System Process Positive Regulation Of Cytokine Production Cell Death Death Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production Nucleotide-excision Repair Regulation Of Cytokine Production Viral Process Regulation Of Type I Interferon Production Regulation Of Gene Expression Cellular Response To Stress Response To Stimulus Stem Cell Maintenance Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Innate Immune Response Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Superoxide Anion Generation Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Tail-anchored Membrane Protein Insertion Into ER Membrane MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Stem Cell Development Transcription, DNA-templated Protein Insertion Into ER Membrane	7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Nucleotide-excision Repair Stem Cell Maintenance Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Stem Cell Development MRNA Metabolic Process Stem Cell Differentiation RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process DNA Repair RNA Splicing Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Differentiation NcRNA Metabolic Process Cellular Response To DNA Damage Stimulus Viral Process DNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Development Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Differentiation Response To Stress Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Developmental Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter RNA Metabolic Process Transcription, DNA-templated
Tagcloud ?			adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 pla2g10 rpl14 rpl41 rpl8 rps17 rps24 rps5 snrpa srp9 ssh subtractive underexpressed zbtb11 zip14
Tagcloud (Difference) ?			adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 pla2g10 rpl14 rpl41 rpl8 rps17 rps24 rps5 snrpa srp9 ssh subtractive underexpressed zbtb11 zip14
Tagcloud (Intersection) ?