POLR2I and ZNF536

		POLR2I	ZNF536
Description		RNA polymerase II subunit I	zinc finger protein 536
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Nucleolus	Nucleus
	Molecular Function	Nucleic Acid Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding Metal Ion Binding
	Biological Process	Maintenance Of Transcriptional Fidelity During Transcription Elongation By RNA Polymerase II Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Neuron Differentiation Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS			Adult body size ( 32376654) Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Age-related hearing impairment ( 24939585) Atorvastatin-induced myopathy ( 31220337) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Chin dimples ( 27182965) Chronotype ( 30696823) Falling risk ( 32999390) General risk tolerance (MTAG) ( 30643258) High density lipoprotein cholesterol levels ( 34074324) Major depressive disorder ( 27479909) Myocardial infarction in hypertension (calcium channel blocker interaction) ( 26516778) Myopia (pathological) ( 23049088) Obesity-related traits ( 23251661) Remission after SSRI treatment in major depression ( 30034349) Schizophrenia ( 29483656 30285260 28991256 25056061) Select biomarker traits ( 17903293) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 27195708)
Interacting Genes		2 interacting genes: POLR2H TBCD	1 interacting genes: GGA2
Entrez ID		5438	9745
HPRD ID		15944	15825
Ensembl ID		ENSG00000105258	ENSG00000198597
Uniprot IDs		P36954	A0A994J7Z0 K7EQN6 O15090
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		RNA Polymerase III Complex RNA Polymerase I Complex RNA Polymerase II, Core Complex Adherens Junction Assembly Negative Regulation Of Microtubule Polymerization Post-chaperonin Tubulin Folding Pathway Tubulin Complex Assembly Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Retinoic Acid-responsive Element Binding Regulation Of Retinoic Acid Receptor Signaling Pathway	Maintenance Of Transcriptional Fidelity During Transcription Elongation By RNA Polymerase II
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