UBL3 and RNF126

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBL3	RNF126
Description		ubiquitin like 3	ring finger protein 126
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Biliary atresia ( 20460270) Blood osmolality (transformed sodium) ( 28360221) Height ( 28552196) Left ventricular mass x antihypertensive treatment interaction ( 31407531) Male-pattern baldness ( 27182965) Non-word repetition ( 23738518) Perceived sweetness of sucrose ( 31005972)	Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)
Interacting Genes		7 interacting genes: APP GORASP2 HDAC7 M1AP RBFOX1 RNF126 SNCA	42 interacting genes: ABCG2 AICDA BAG6 CENPP CSNK2B E2F1 EGFR FXN G0S2 HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SFN SNUPN TARDBP TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6
Entrez ID		5412	55658
HPRD ID		05275	11501
Ensembl ID		ENSG00000122042	ENSG00000070423
Uniprot IDs		O95164	A8K0Q1 Q9BV68
PDB IDs		2GOW	2N9O 2N9P
Enriched GO Terms of Interacting Partners?		Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Cellular Response To Copper Ion Response To Copper Ion Leukocyte Activation Involved In Inflammatory Response Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Male Meiosis Chromosome Separation Adult Locomotory Behavior Response To Interleukin-1 Protein Tetramerization Cell Junction Organization Acetylcholine Receptor Activator Activity Regulation Of Non-canonical NF-kappaB Signal Transduction Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process PTB Domain Binding Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Adult Behavior Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Growth Cone	Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Cytosol Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Damage Response Protein K11-linked Ubiquitination Nucleus Negative Regulation Of Metabolic Process Ubiquitin Binding Transferase Activity Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K63-linked Ubiquitination Catabolic Process Protein-containing Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Nucleoplasm Cellular Response To Stress Regulation Of Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Protein Catabolic Process Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process
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