C21orf58 and KRT35

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C21orf58	KRT35
Description		chromosome 21 open reading frame 58	keratin 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function		Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process		Morphogenesis Of An Epithelium Anatomical Structure Morphogenesis Epithelial Cell Differentiation Intermediate Filament Organization
Pathways			Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: CCDC125 CCDC136 GRB2 KLHL20 KRT27 KRT35 KRT37 MKRN3 MTUS2 PNMA1 POLR1C SPTA1 TRIB3 USHBP1	88 interacting genes: ABI3 AIRIM ATG9A BCAS2 C21orf58 CCDC120 CCDC185 CCDC196 CCHCR1 CD33 CTSZ DMRT3 DTNB EFCAB3 ENKD1 EXOSC5 FAM221B FRS3 HAPLN2 HCK HDAC4 HGS HOXA1 HOXC8 KCTD9 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LENG1 LGALS14 LONRF1 MAPKBP1 MCRS1 MYO15B OIP5 OTX1 PKN1 POU4F2 PRPF18 PRPF31 PRR35 RUNX1T1 SCNM1 SHC3 SLC43A2 SMARCE1 SMYD1 TAPBPL TBC1D21 TBC1D30 TBC1D7 TCEANC TCHP TEKT4 TEPSIN TLE5 TRIM29 TSG101 TXLNA TXLNB UBASH3A USP2 VPS9D1 ZNF417 ZNF446
Entrez ID		54058	3886
HPRD ID		10755	04138
Ensembl ID		ENSG00000160298	ENSG00000197079
Uniprot IDs		P58505	Q92764
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Cytoskeleton Organization Morphogenesis Of An Epithelium Tissue Morphogenesis Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Guanyl-nucleotide Exchange Factor Adaptor Activity Type II Interferon Binding	Structural Constituent Of Skin Epidermis Keratin Filament Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Protein Binding Epidermis Development Intermediate Filament Cytoskeleton Cornified Envelope Negative Regulation Of Cilium Assembly Regulation Of Organelle Assembly Extracellular Exosome
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