PPIL3 and ALS2

		PPIL3	ALS2
Description		peptidylprolyl isomerase like 3	alsin Rho guanine nucleotide exchange factor ALS2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome	Ruffle Nucleus Cytoplasm Early Endosome Centrosome Cytosol Postsynaptic Density Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Dendritic Spine Intracellular Membrane-bounded Organelle Glutamatergic Synapse
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing	Behavioral Fear Response Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Neuromuscular Junction Development Locomotory Behavior Intracellular Protein Localization Vesicle Organization Endosomal Transport Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Regulation Of Biological Quality Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		mRNA Splicing - Major Pathway	RAB GEFs exchange GTP for GDP on RABs RAC1 GTPase cycle
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)	Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)
Interacting Genes		10 interacting genes: CENATAC DMRTB1 PCBP1 PHC1 RPS13 SHARPIN SLU7 TAB2 TAB3 YTHDF1	1 interacting genes: YWHAB
Entrez ID		53938	57679
HPRD ID		15163	05893
Ensembl ID		ENSG00000240344	ENSG00000003393
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	A0A7P0T8F3 A0A7P0Z4I4 A8K4R4 Q96Q42
PDB IDs		1XYH 2OJU 2OK3 8C6J
Enriched GO Terms of Interacting Partners?			IMP Dehydrogenase Activity Nuclear Migration Along Microfilament Nuclear Migration Along Microtubule Nuclear Matrix Organization Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Nuclear Matrix Anchoring At Nuclear Membrane GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process Phosphoserine Residue Binding Cytoskeleton-nuclear Membrane Anchor Activity Meiotic Nuclear Membrane Microtubule Tethering Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?