PPIL3 and NUP107

		PPIL3	NUP107
Description		peptidylprolyl isomerase like 3	nucleoporin 107
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GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Chromosome Cytosol Membrane Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing	Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Female Gonad Development Protein Transport MRNA Transport Nuclear Pore Complex Assembly Nephron Development
Pathways		mRNA Splicing - Major Pathway	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)	White blood cell count ( 20139978)
Interacting Genes		10 interacting genes: CENATAC DMRTB1 PCBP1 PHC1 RPS13 SHARPIN SLU7 TAB2 TAB3 YTHDF1	4 interacting genes: APAF1 NUP133 NUP214 SUMO2
Entrez ID		53938	57122
HPRD ID		15163	06356
Ensembl ID		ENSG00000240344	ENSG00000111581
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	P57740
PDB IDs		1XYH 2OJU 2OK3 8C6J	3CQC 3CQG 3I4R 5A9Q 7PEQ 7R5J 7R5K
Enriched GO Terms of Interacting Partners?			Structural Constituent Of Nuclear Pore Response To G1 DNA Damage Checkpoint Signaling RNA Export From Nucleus Cytoplasmic Side Of Nuclear Pore MRNA Export From Nucleus Nuclear Pore Protein Import Into Nucleus Import Into Nucleus MRNA Transport Nuclear Export RNA Transport Apoptosome Protein Localization To Nucleus Nucleobase-containing Compound Transport Nuclear Envelope Response To DNA Damage Checkpoint Signaling Nuclear Transport Nucleocytoplasmic Transport Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Paraxial Mesoderm Development Regulation Of Apoptotic DNA Fragmentation Cysteine-type Endopeptidase Activator Activity Nuclear Pore Outer Ring Cardiac Muscle Cell Apoptotic Process Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Establishment Of Protein Localization To Organelle Nuclear Export Signal Receptor Activity Nephron Development Striated Muscle Cell Apoptotic Process Nuclear Pore Organization Protein Tag Activity Somite Development Muscle Cell Apoptotic Process SUMO Transferase Activity Nuclear Localization Sequence Binding Poly(A)+ MRNA Export From Nucleus Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Intracellular Protein Transport Protein Export From Nucleus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Peptidyl-prolyl Cis-trans Isomerase Activity
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