YME1L1 and BCL11A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		YME1L1	BCL11A
Gene Name		YME1-like 1 ATPase	B-cell CLL/lymphoma 11A (zinc finger protein)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Metalloendopeptidase Activity ATP Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Misfolded Or Incompletely Synthesized Protein Catabolic Process Mitochondrion Organization Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Protein Sumoylation B Cell Differentiation T Cell Differentiation Negative Regulation Of Axon Extension Negative Regulation Of Protein Homooligomerization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Collateral Sprouting Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Development Negative Regulation Of Dendrite Development
Pathways
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 22012869) Beta thalassemia/hemoglobin E disease ( 20183929) F-cell distribution ( 21326311 17767159) Fetal hemoglobin levels ( 18245381 20018918) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Mean corpuscular volume ( 19862010) Monocyte early outgrowth colony forming units ( 21493818) Red blood cell traits ( 23222517) Sickle cell anemia (haemolysis) ( 23406172) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		3 interactors: BCL11A MYOG PSEN1	20 interactors: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 GMCL1P1 LMO1 NCK2 NR2E1 NR2E3 NR2F1 NR2F2 NR2F6 SIRT1 SUMO1 SUMO2 SUMO3 YME1L1 ZBTB24
Entrez ID		10730	53335
HPRD ID		06981	05949
Ensembl ID		ENSG00000136758	ENSG00000119866
Uniprot IDs		Q96TA2	D6W5D9 D9YZV9 Q9H165
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Axonogenesis Regulation Of Cell Development Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Projection Organization Cajal-Retzius Cell Differentiation Beta-amyloid Formation Positive Regulation Of Muscle Atrophy Regulation Of Axonogenesis Negative Regulation Of Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Negative Regulation Of Neurogenesis Cell Fate Commitment Synaptic Vesicle Targeting Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Resting Membrane Potential Regulation Of Transcription From RNA Polymerase II Promoter Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Regulation Of Cellular Component Organization Leukocyte Differentiation Negative Regulation Of Cell Development Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Choline Transport Regulation Of Neuron Projection Development Negative Regulation Of Collateral Sprouting Positive Regulation Of Skeletal Muscle Fiber Development Striated Muscle Atrophy Lymphocyte Activation Muscle Atrophy Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Amyloid Precursor Protein Catabolic Process Regulation Of Satellite Cell Proliferation Negative Regulation Of Protein Oligomerization Response To Denervation Involved In Regulation Of Muscle Adaptation Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Leukocyte Activation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Development Positive Regulation Of Collateral Sprouting Response To Inactivity Single Organismal Cell-cell Adhesion	Positive Regulation Of Cellular Metabolic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Cellular Senescence Positive Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Aging Negative Regulation Of Cellular Metabolic Process Cell Differentiation Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Senescence Protein Sumoylation Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Steroid Hormone Multicellular Organismal Development Generation Of Neurons Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Neurogenesis System Development Positive Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Organ Development Response To Hormone Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Forebrain Development Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		accompanying afg3l2 bidirectional bp chop coordinately cpn60 dimerise ebp element elements encoding endonuclease exception hetero import lies lon mtupr ndufb2 paraplegin promoters proteases responsive sam share thioredoxin tim17a unfolded	beadchip cpgs cues enhancers erythroblasts erythroid erythropoiesis fetal globin happen hbf hemoglobin highlighting humanmethylation illumina maps mendelian methylated methylation methylome moves overlap red repress sickle switch tend thalassemia unanticipated
Tagcloud (Difference) ?		accompanying afg3l2 bidirectional bp chop coordinately cpn60 dimerise ebp element elements encoding endonuclease exception hetero import lies lon mtupr ndufb2 paraplegin promoters proteases responsive sam share thioredoxin tim17a unfolded	beadchip cpgs cues enhancers erythroblasts erythroid erythropoiesis fetal globin happen hbf hemoglobin highlighting humanmethylation illumina maps mendelian methylated methylation methylome moves overlap red repress sickle switch tend thalassemia unanticipated
Tagcloud (Intersection) ?