PGD and ALG5

		PGD	ALG5
Description		phosphogluconate dehydrogenase	ALG5 dolichyl-phosphate beta-glucosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane
	Molecular Function	Phosphogluconate Dehydrogenase (decarboxylating) Activity Oxidoreductase Activity Carbohydrate Binding Carboxylic Acid Binding NADP Binding	Dolichyl-phosphate Beta-glucosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity
	Biological Process	Pentose-phosphate Shunt NADP+ Metabolic Process NADPH Regeneration Pentose-phosphate Shunt, Oxidative Branch Pentose Biosynthetic Process D-gluconate Metabolic Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Determination Of Left/right Symmetry Protein N-linked Glycosylation Via Asparagine
Pathways		Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes	Synthesis of dolichyl-phosphate-glucose
Drugs		Gadopentetic acid Dacarbazine Ketotifen 6-phospho-D-gluconic acid Nicotinamide 8-bromo-adenine dinucleotide phosphate
Diseases
GWAS		Hemoglobin ( 32888494) Hepatocellular carcinoma ( 20676096) Metabolite levels ( 23823483)	Interleukin-10 levels ( 22205395)
Interacting Genes		8 interacting genes: CDC42 CDK4 GBE1 LINC00632 LINC01554 LSM8 OGT TERF1
Entrez ID		5226	29880
HPRD ID		01391	05193
Ensembl ID		ENSG00000142657	ENSG00000120697
Uniprot IDs		B4E2U0 P52209	Q9Y673
PDB IDs		2JKV 4GWG 4GWK 5UQ9
Enriched GO Terms of Interacting Partners?		Glycosyltransferase Activity 1,4-alpha-glucan Branching Enzyme Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glycosylation-dependent Protein Binding Dolichyl-phosphate Beta-glucosyltransferase Activity GBD Domain Binding Storage Vacuole Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication	Carbohydrate Binding Pentose-phosphate Shunt, Oxidative Branch Pentose Biosynthetic Process D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Cellular Response To Vitamin K Bone Regeneration Oocyte Differentiation Response To Vitamin K Pentose Metabolic Process Carboxylic Acid Binding Regulation Of Opsonization Serine-type Endopeptidase Complex Positive Regulation Of Opsonization Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Complement Activation, Lectin Pathway Pentose-phosphate Shunt Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
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