LRR1 and TNFRSF9

Number of citations of the paper that reports this interaction (PubMedID 11804328)
0

Data Source:
HPRD (two hybrid, in vitro)

		LRR1	TNFRSF9
Description		leucine rich repeat protein 1	TNF receptor superfamily member 9
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GO Annotations	Cellular Component	Nucleus Cytosol	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	TNFs bind their physiological receptors
Drugs			Urelumab
Diseases
GWAS			Blond vs. brown/black hair color ( 30531825) Celiac disease ( 20190752) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Psoriasis ( 23143594 25903422) Rheumatoid arthritis ( 24390342 30423114) Ulcerative colitis ( 21297633 28067908) Waist-hip ratio ( 28552196)
Interacting Genes		9 interacting genes: CDKN1A MCM7 MTUS2 PFKFB4 PNMA2 TNFRSF9 TRIP13 UBC UBE2D1	7 interacting genes: LRR1 SERP1 TNFRSF4 TNFSF9 TRAF1 TRAF2 TRAF3
Entrez ID		122769	3604
HPRD ID		15164	03767
Ensembl ID		ENSG00000165501	ENSG00000049249
Uniprot IDs		A0A384MTQ0 Q96L50	Q07011
PDB IDs		7PLO	6A3V 6A3W 6BWV 6CPR 6CU0 6MGP 6MHR 6MI2 6Y8K 7D4B 7YXU 8GYE 8OZ3
Enriched GO Terms of Interacting Partners?			Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Photoreactive Repair Adenine/guanine Mispair Binding TORC2 Complex Disassembly Positive Regulation Of Synaptic Transmission, Glycinergic D-serine Transmembrane Transport D-alanine Transmembrane Transport Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly Regulation Of Immunoglobulin Production CD40 Receptor Binding Positive Regulation Of Cytotoxic T Cell Differentiation Regulation Of Synaptic Transmission, Glycinergic Cry-Per Complex Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) MutLbeta Complex Binding MutSbeta Complex Binding Protein Phosphatase Binding Mpp10 Complex Protein Secretion Protein Localization To Extracellular Region Basolateral Protein Secretion Establishment Of Protein Localization To Extracellular Region Negative Regulation Of Glucocorticoid Secretion Regulation Of Sodium-dependent Phosphate Transport Isocitrate Metabolic Process Depurination Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex Sphingolipid Binding Cytoplasmic Side Of Plasma Membrane IRE1-TRAF2-ASK1 Complex
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