RTEL1 and RAE1

		RTEL1	RAE1
Description		regulator of telomere elongation helicase 1	ribonucleic acid export 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Speck Nuclear Membrane	Spindle Pole Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoskeleton Mitotic Spindle Pole
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding DNA Polymerase Binding	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding
	Biological Process	Regulation Of DNA Recombination Telomere Maintenance DNA Strand Displacement Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Replication Fork Processing Positive Regulation Of Telomere Maintenance Telomere Maintenance In Response To DNA Damage Negative Regulation Of DNA Recombination Regulation Of Cellular Response To Stress Telomeric Loop Disassembly Mitotic Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomere Capping Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Telomeric Loop Disassembly	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Nucleocytoplasmic Transport Cell Division Regulation Of Mitotic Spindle Organization
Pathways		Telomere Extension By Telomerase Cytosolic iron-sulfur cluster assembly Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Adult diffuse glioma (IDH wildtype) ( 32386320) Adult diffuse glioma (TERT mutation only) ( 32386320) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Anorectal malformation ( 31136621) Asthma ( 32296059 31619474 31361310 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Crohn's disease ( 21102463 28067908) Cutaneous malignant melanoma ( 26237428 32341527) Dental caries ( 23259602) Eczema ( 31361310) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 19578367 28346443 21531791 29743610 30714141 22886559) Glioma (high-grade) ( 19578366 24908248) Idiopathic pulmonary fibrosis ( 31710517) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 31171785 32109421) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527) Non-glioblastoma glioma ( 29743610 28346443) Plateletcrit ( 27863252 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Telomere length ( 29151059) Ulcerative colitis ( 28067908 21297633)
Interacting Genes			14 interacting genes: BDKRB1 BUB1 CEBPA DDX24 DHFR EIF4ENIF1 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 RNU1-1 TRF-GAA1-1
Entrez ID		51750	8480
HPRD ID		15281	11939
Ensembl ID		ENSG00000258366	ENSG00000101146
Uniprot IDs		Q9NZ71 R4IXY3	P78406
PDB IDs		7WU8 8P8H 8YA8	3MMY 4OWR 7F60 7F90 7VPG 7VPH
Enriched GO Terms of Interacting Partners?		Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Fibrillar Center Ubiquitin Binding RNA Export From Nucleus MRNA Export From Nucleus RNA Transport Regulation Of Microtubule Cytoskeleton Organization MRNA Transport Regulation Of Mitotic Spindle Organization Nuclear Export Mitotic Spindle Pole Spindle Pole Nuclear Pore Regulation Of Microtubule-based Process Nuclear Transport Nucleocytoplasmic Transport Microtubule Binding Nucleobase-containing Compound Transport Nuclear Envelope Chromosome Organization	MRNA Binding Positive Regulation Of Chromosome Organization Kinase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Peptide Binding Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Nuclear Export Telomere Tethering At Nuclear Periphery Import Into Nucleus Protein Import Into Nucleus Protein Serine Kinase Activity (using GTP As Donor) Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity DNA Strand Displacement Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Prolactin Signaling Pathway Response To Dexamethasone Protein Localization To Nucleus
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