CDK5RAP1 and NKX2-2

		CDK5RAP1	NKX2-2
Description		CDK5RAP1 mitochondrial tRNA methylthiotransferase	NK2 homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	Catalytic Activity Transferase Activity Protein Kinase Binding Methylthiotransferase Activity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	TRNA Modification Brain Development TRNA Processing RNA Modification TRNA Methylthiolation Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Translational Fidelity Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Modification	Type B Pancreatic Cell Differentiation Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Nervous System Development Brain Development Response To Glucose Positive Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Positive Regulation Of Epithelial Cell Differentiation Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination Neuroendocrine Cell Differentiation
Pathways			Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Hip circumference adjusted for BMI ( 25673412 34021172) Mean corpuscular volume ( 32888494)	Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: CDK5 CDK5R1 EXOSC3 EXOSC5	1 interacting genes: OLIG2
Entrez ID		51654	4821
HPRD ID		12189	05213
Ensembl ID		ENSG00000101391	ENSG00000125820
Uniprot IDs		A0A0S2Z592 A0A0S2Z5J9 Q53H36 Q96SZ6	O95096
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase 5 Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity DNA Deamination Nucleolar Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Layer Formation In Cerebral Cortex SnRNA 3'-end Processing Positive Regulation Of Protein Targeting To Membrane DNA Modification Ionotropic Glutamate Receptor Binding 3'-5'-RNA Exonuclease Activity Regulation Of Protein Targeting To Membrane SnRNA Processing Nuclear RNA Surveillance RNA Surveillance Regulation Of Dendritic Spine Morphogenesis Oligodendrocyte Differentiation Cyclin-dependent Protein Kinase Holoenzyme Complex SnRNA Metabolic Process Cerebellum Development Euchromatin Glial Cell Development Neuron Differentiation Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Hippocampus Development Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Neuromuscular Junction RNA 3'-end Processing Microtubule Cytoskeleton Organization Acetylcholine Receptor Activator Activity Glial Cell Differentiation Cell Projection Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Superior Olivary Nucleus Maturation Nuclear-transcribed MRNA Catabolic Process Regulation Of Developmental Process ErbB-2 Class Receptor Binding Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Epithelial Cell Development Spinal Cord Oligodendrocyte Cell Fate Specification	Double-stranded DNA Helicase Activity DNA/DNA Annealing Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Spinal Cord Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Methylthiotransferase Activity TRNA Methylthiolation Negative Regulation Of Phosphate Metabolic Process Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Assembly Four-way Junction Helicase Activity Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Glial Cell Fate Specification Regulation Of Neuron Differentiation
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