RTRAF and TAOK2

		RTRAF	TAOK2
Description		RNA transcription, translation and transport factor	TAO kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Perinuclear Region Of Cytoplasm TRNA-splicing Ligase Complex Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Receptor Complex Dendritic Growth Cone Axonal Growth Cone
	Molecular Function	RNA Polymerase II Complex Binding RNA Binding Protein Binding Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Binding Neuropilin Binding Protein Serine/threonine Kinase Activator Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II RNA Transport	Regulation Of Cell Growth Protein Targeting To Membrane Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Axonogenesis Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Focal Adhesion Assembly Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Stress-activated MAPK Cascade Basal Dendrite Morphogenesis Basal Dendrite Arborization
Pathways		tRNA processing in the nucleus
Drugs			Dexfosfoserine Fostamatinib
Diseases
GWAS			Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Metabolic syndrome ( 31589552) Schizophrenia ( 30285260 29483656 28991256 25056061) Triglyceride levels ( 32154731 32203549) Waist circumference ( 31928498)
Interacting Genes		7 interacting genes: CEBPA DISC1 GLP1R MTNR1A NIN PCNT PSORS1C2	12 interacting genes: CIDEB ELK1 KLHL12 KRTAP6-3 MAP2K3 MAP2K6 MEGF10 RCHY1 TUBA1A TUBA4A TUBB USF1
Entrez ID		51637	9344
HPRD ID		16615	18147
Ensembl ID		ENSG00000087302	ENSG00000149930
Uniprot IDs		Q549M8 Q9Y224	Q9UL54
PDB IDs		7P3A
Enriched GO Terms of Interacting Partners?		Microtubule Nucleation Axonal Growth Cone CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Microtubule Microtubule Organizing Center Cell Projection Organization Cytoskeleton Organization Microtubule Cytoskeleton Organization Axon Basal Dendrite Morphogenesis Basal Dendrite Arborization Pyramidal Neuron Migration To Cerebral Cortex Positive Regulation Of Axonogenesis Central Region Of Growth Cone Centrosome-templated Microtubule Nucleation Organelle Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Psychosocial Stress Melatonin Receptor Activity Centrosome Centriole Cytoskeleton Axonogenesis Radial Glia-guided Pyramidal Neuron Migration Regulation Of Axonogenesis Corticospinal Tract Morphogenesis Microtubule Nucleation By Microtubule Organizing Center Corpus Callosum Morphogenesis Response To Phenylpropanoid Fat Cell Proliferation Post-translational Protein Targeting To Membrane, Translocation Receptor Complex Molecular Adaptor Activity Dendritic Growth Cone Cerebral Cortex Radial Glia-guided Migration Ciliary Transition Fiber Positive Regulation Of Proteolysis	Response To Light Stimulus NLRP1 Inflammasome Complex Assembly Response To Radiation Cellular Response To UV-B MAP Kinase Kinase Activity COPII Vesicle Coat Structural Constituent Of Cytoskeleton Response To UV-B Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade
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