LARP7 and GAR1

Number of citations of the paper that reports this interaction (PubMedID 29845934)
80

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		LARP7	GAR1
Description		La ribonucleoprotein 7, transcriptional regulator	GAR1 ribonucleoprotein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol 7SK SnRNP Ribonucleoprotein Complex	Chromosome, Telomeric Region Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding U6 SnRNA Binding 7SK SnRNA Binding	RNA Binding Protein Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Box C/D Sno(s)RNA 3'-end Processing RNA Processing MRNA Processing Spermatogenesis RNA Splicing Cell Differentiation Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II U6 2'-O-snRNA Methylation	SnoRNA Guided RRNA Pseudouridine Synthesis Pseudouridine Synthesis RRNA Processing Telomere Maintenance Via Telomerase Ribosome Biogenesis
Pathways			Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Dental caries (decayed and filled deciduous teeth) ( 31533690) Meat-related diet ( 32066663) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		79 interacting genes: APP BARD1 BRCA1 JMJD6 LRRK2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRPF40A RN7SK WEE2-AS1	7 interacting genes: DSCR9 FOXP1 NEAT1 PCBP2 SMN1 SMN2 UBC
Entrez ID		51574	54433
HPRD ID		17095	07569
Ensembl ID		ENSG00000174720	ENSG00000109534
Uniprot IDs		A0A8I5KUI4 A0A8Q3SHH4 A0A8Q3SHN7 H0YA82 Q4G0J3	Q9NY12
PDB IDs		4WKR 5KNW 6D12 7SLP 7SLQ	7BGB 7TRC 7V9A 8OUE 8OUF
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Gene Expression Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Cytokine Production Negative Regulation Of Vasculature Development Negative Regulation Of Cell Motility Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Cytokine Production Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion	SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex DNA-templated Transcription Termination MRNA Metabolic Process Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly RNA Binding Cajal Body RNA Splicing U6 2'-O-snRNA Methylation Cytoplasmic Ribonucleoprotein Granule MRNA Processing Positive Regulation Of Interleukin-21 Production Box C/D Sno(s)RNA 3'-end Processing MiRNA Inhibitor Activity Via Base-pairing RNA Metabolic Process Perikaryon Z Disc Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP RISC Complex Binding Positive Regulation Of Synoviocyte Proliferation LncRNA-mediated Post-transcriptional Gene Silencing Nucleoplasm Promoter-enhancer Loop Anchoring Activity Regulation Of Macrophage Colony-stimulating Factor Production SnRNA Modification Positive Regulation Of MiRNA Catabolic Process Viral RNA Genome Replication Osteoclast Development Regulation Of Endothelial Tube Morphogenesis Protein-RNA Complex Assembly Positive Regulation Of B Cell Receptor Signaling Pathway RNA Splicing, Via Transesterification Reactions Monocyte Activation Endothelial Cell Activation 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body Paraspeckles Regulation Of MRNA Export From Nucleus IRES-dependent Viral Translational Initiation T Follicular Helper Cell Differentiation Regulation Of Defense Response RNA Processing Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development U6 SnRNA Binding Negative Regulation Of B Cell Apoptotic Process
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