RAB14 and ARHGEF17

		RAB14	ARHGEF17
Description		RAB14, member RAS oncogene family	Rho guanine nucleotide exchange factor 17
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Cilium Endomembrane System Membrane Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Phagolysosome Assembly Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Protein Transport Vesicle-mediated Transport Endocytic Recycling Regulation Of Protein Localization Endosomal Vesicle Fusion Early Endosome To Golgi Transport Defense Response To Bacterium Regulation Of Embryonic Development Intracellular Transport Phagosome Maturation	Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)	FEV1 ( 30804560) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: ADRB2 APP ARL8B CHM EXOC5 GARIN6 OCRL OPTN RAB11FIP5 RBSN RUFY1 SH3BP5L SMURF2	3 interacting genes: OTX1 RHOA USP7
Entrez ID		51552	9828
HPRD ID		06693	10658
Ensembl ID		ENSG00000119396	ENSG00000110237
Uniprot IDs		P61106	Q96PE2
PDB IDs		1Z0F 4D0G 4DRZ
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endosome Early Endosome Membrane Early Endosome To Golgi Transport Early Endosome Small GTPase Binding Golgi Vesicle Transport Cellular Response To Amyloid-beta Response To Amyloid-beta Innate Immune Response Response To Mechanical Stimulus Positive Regulation Of CAMP/PKA Signal Transduction Golgi-associated Vesicle Defense Response To Symbiont Defense Response To Gram-negative Bacterium Protein Transport Endosomal Vesicle Fusion Cellular Localization Defense Response To Other Organism Retrograde Transport, Endosome To Golgi Platelet Alpha Granule Post-Golgi Vesicle-mediated Transport Neuronal Dense Core Vesicle Defense Response To Bacterium Lysosomal Transport Establishment Of Protein Localization Cytosolic Transport Recycling Endosome Amyloid Fibril Formation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Ligand-gated Ion Channel Signaling Pathway Vacuolar Transport Negative Regulation Of Cell Communication Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Signaling Amyloid-beta Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Bacterium Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Blood Coagulation, Common Pathway Membrane Organization Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding	Beta Selection Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein Activity Positive Regulation Of Vascular Associated Smooth Muscle Contraction Organelle Assembly Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Skeletal Muscle Satellite Cell Migration Metencephalon Development Diencephalon Morphogenesis Vacuole Organization Symbiont-mediated Disruption Of Host Cell PML Body Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Bone Trabecula Morphogenesis Phagolysosome Assembly Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Positive Regulation Of Lipase Activity Cleavage Furrow Formation Regulation Of Systemic Arterial Blood Pressure By Endothelin Negative Regulation Of Cell Size Apical Junction Assembly GTPase Activity Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Establishment Of Protein Localization To Chromosome Monoubiquitinated Protein Deubiquitination Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Modification Of Postsynaptic Structure Motor Neuron Apoptotic Process Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Regulation Of Motor Neuron Apoptotic Process Cellular Response To Chemokine Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Vascular Associated Smooth Muscle Contraction Hydrolase Activity Negative Regulation Of Motor Neuron Apoptotic Process Heart Valve Formation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process GTP Binding Endothelial Tube Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Radial Glial Cell Differentiation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
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