PLA1A and ANXA2

Number of citations of the paper that reports this interaction (PMID 1531641)
1

Data Source:
HPRD (in vitro, in vivo)

		PLA1A	ANXA2
Gene Name		phospholipase A1 member A	annexin A2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Membrane Extracellular Vesicular Exosome	Ruffle Basement Membrane Extracellular Space Nucleus Lysosomal Membrane Endosome Early Endosome Lipid Particle Plasma Membrane Cell Cortex Cell Surface Membrane Extrinsic Component Of Plasma Membrane Midbody Extracellular Matrix Late Endosome Membrane Vesicle Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Protein Complex Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylcholine 1-acylhydrolase Activity	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Rab GTPase Binding Phospholipase A2 Inhibitor Activity S100 Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidylserine Metabolic Process Lipid Catabolic Process	Angiogenesis Membrane Raft Assembly Positive Regulation Of Protein Phosphorylation Membrane Budding Body Fluid Secretion Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Osteoclast Development Fibrinolysis Negative Regulation Of Catalytic Activity Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Binding Protein Heterotetramerization Protein Targeting To Plasma Membrane
Pathways			Dissolution of Fibrin Clot Orphan transporters
Drugs			Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ANXA2 APP	31 interactors: APOH APP CD99 CDC42 CEACAM1 CTSB DYSF GRB2 HMGA1 LGALS13 LYPLA1 MAP3K4 MYOC PHB PLA1A PLAT PLG POT1 PRKCA PRKCB S100A10 S100A4 S100A6 SOS1 SRC STAT6 TERF1 TERT TP53 TRPV5 YWHAQ
Entrez ID		51365	302
HPRD ID		07078	01061
Ensembl ID		ENSG00000144837	ENSG00000182718
Uniprot IDs		Q53H76	P07355
PDB IDs			1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4HRH
Enriched GO Terms of Interacting Partners?		Regulation Of Binding Synaptic Growth At Neuromuscular Junction Extracellular Matrix Organization Extracellular Structure Organization Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Body Fluid Levels Secretion Neuron Remodeling Osteoclast Development Membrane Raft Assembly Negative Regulation Of Catalytic Activity Protein Heterotetramerization Fibrinolysis Cellular Copper Ion Homeostasis Membrane Raft Organization Positive Regulation Of Vesicle Fusion Membrane Assembly Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Phosphorylation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Membrane Biogenesis Positive Regulation Of Cellular Protein Metabolic Process Protein Targeting To Plasma Membrane Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorylation RNA Polyadenylation Neuron Recognition Regulation Of Vesicle Fusion Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Blood Coagulation Ionotropic Glutamate Receptor Signaling Pathway Vesicle-mediated Transport Osteoclast Differentiation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Negative Regulation Of Coagulation Regulation Of Cell Cycle G2/M Phase Transition Collagen Fibril Organization Intracellular Transport Axon Cargo Transport	Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Cellular Component Biogenesis Leukocyte Migration Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization ERBB Signaling Pathway Cell Activation Regulation Of Signaling Telomere Maintenance Via Telomerase Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Developmental Process Regulation Of Apoptotic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Histone H3-T6 Phosphorylation Cellular Component Assembly Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway Cell Aging Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity RNA-dependent DNA Replication Regulation Of ERBB Signaling Pathway Age-dependent Telomere Shortening Telomere Formation Via Telomerase Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Adhesion Immune System Process Cell Migration Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Organization
Tagcloud ?			annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Difference) ?			annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Intersection) ?