AHSP and ZC3H12A

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		AHSP	ZC3H12A
Gene Name		alpha hemoglobin stabilizing protein	zinc finger CCCH-type containing 12A
Image
Gene Ontology Annotations	Cellular Component	Hemoglobin Complex	Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Hemoglobin Binding Unfolded Protein Binding	Endonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Hemoglobin Metabolic Process Hemopoiesis Protein Stabilization	Angiogenesis Apoptotic Process Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Lipid Storage Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Cellular Response To Lipopolysaccharide Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: FKBP1A HBA2 POLR2M TMEM165 UBE3A ZC3H12A	13 interactors: AHSP AIMP2 BTRC CYFIP2 EP300 IKBKG IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK UBC
Entrez ID		51327	80149
HPRD ID		12052	08021
Ensembl ID		ENSG00000169877	ENSG00000163874
Uniprot IDs		Q549J4 Q9NZD4	Q5D1E8
PDB IDs		1W09 1W0A 1W0B 1XZY 1Y01 1Z8U 3IA3 3OVU	3V32 3V33 3V34
Enriched GO Terms of Interacting Partners?		Maintenance Of ER Location Sperm Entry Golgi Calcium Ion Transport Negative Regulation Of Protein Phosphatase Type 2B Activity Endoplasmic Reticulum Localization Amyloid Fibril Formation Regulation Of Protein Ubiquitination Regulation Of Lysosomal Lumen PH Negative Regulation Of Macrophage Activation Cellular Calcium Ion Homeostasis Negative Regulation Of Phosphoprotein Phosphatase Activity Calcium Ion Homeostasis Calcium Ion Transport Protein Maturation By Protein Folding SMAD Protein Complex Assembly Extracellular Fibril Organization	I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Viral Process Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Innate Immune Response-activating Signal Transduction Regulation Of Protein Stability Activation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Immune Response Regulation Of Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Apoptotic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Positive Regulation Of Type I Interferon Production JNK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune Response Protein Stabilization Regulation Of Type I Interferon Production Regulation Of Immune System Process Positive Regulation Of Cytokine Production Stress-activated MAPK Cascade G2/M Transition Of Mitotic Cell Cycle Stress-activated Protein Kinase Signaling Cascade Defense Response
Tagcloud ?		chains elution erythropoiesis excess globin gst hb hemoglobin hemolysates imbalance incubated inefficient lysates micro pool ppm precipitates precursors quantified rbc rbcs spectrophotometry stabilizing thalassemia thalassemias thalassemic unpaired varies washing	attached attenuating cascade ccch chains chemotactic consequences consistently deleterious deubiquitinase deubiquitination elucidated feedback finger genotoxic kappab linear mcpip1 mediating monocyte nemo polyubiquitin promotion serves signalling terminated ubiquitylation uncontrolled usp10
Tagcloud (Difference) ?		elution erythropoiesis excess globin gst hb hemoglobin hemolysates imbalance incubated inefficient lysates micro pool ppm precipitates precursors quantified rbc rbcs spectrophotometry stabilizing thalassemia thalassemias thalassemic unpaired varies washing	attached attenuating cascade ccch chemotactic consequences consistently deleterious deubiquitinase deubiquitination elucidated feedback finger genotoxic kappab linear mcpip1 mediating monocyte nemo polyubiquitin promotion serves signalling terminated ubiquitylation uncontrolled usp10
Tagcloud (Intersection) ?		chains