NME8 and BBS9

		NME8	BBS9
Description		NME/NM23 family member 8	Bardet-Biedl syndrome 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axoneme Nuclear Speck Sperm Flagellum Outer Dynein Arm Sperm Midpiece Sperm Principal Piece Sperm Cytoplasmic Droplet	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Membrane
	Molecular Function	Microtubule Binding 3'-5'-DNA Exonuclease Activity Hydrolase Activity	Molecular_function Protein Binding
	Biological Process	DNA Catabolic Process Spermatogenesis Cell Differentiation Flagellated Sperm Motility Cellular Response To Reactive Oxygen Species Cilium Assembly	Visual Perception Protein Transport Cell Projection Organization Fat Cell Differentiation Cilium Assembly Protein Localization To Cilium
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome	Bardet-Biedl syndrome (BBS)
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30617256) Periodontitis ( 25672891)	Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Asthma ( 29273806) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Disease progression in age-related macular degeneration ( 29346644) Intraocular pressure ( 29785010 31959993) Left–right brain asymmetry ( 33723403) Leprosy ( 27976721) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Metopic nonsyndromic craniosynostosis ( 32266521) Postoperative stroke after cardiac surgery ( 30678657) Sagittal craniosynostosis ( 23160099) Smooth-surface caries ( 24556642) Subcortical volume (MOSTest) ( 32665545) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
Interacting Genes		2 interacting genes: APP RIPK3	2 interacting genes: TOM1 TOM1L2
Entrez ID		51314	27241
HPRD ID		16243	16262
Ensembl ID		ENSG00000086288	ENSG00000122507
Uniprot IDs		Q8N427	A0A090N7W2 A0A090N8P4 A0A5F9ZGY2 A0A5F9ZH14 A0A5F9ZH74 A0A5F9ZHE7 Q3SYG4
PDB IDs			4YD8 6XT9
Enriched GO Terms of Interacting Partners?		Amyloid Fibril Formation Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Regulation Of Type II Interferon Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Regulation Of Lymphocyte Migration Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Reactive Oxygen Species Metabolic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of T Cell Migration Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Execution Phase Of Necroptosis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Succinate-hydroxymethylglutarate CoA-transferase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Leukocyte Migration Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Activation-induced Cell Death Of T Cells Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Positive Regulation Of Necroptotic Process BBSome Heparan Sulfate Binding Signaling Receptor Activator Activity	Regulation Of Macroautophagy Clathrin Binding Regulation Of Autophagy Negative Regulation Of Monocyte Activation Specific Granule Membrane Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Corticotropin Hormone Secreting Cell Differentiation Ubiquitin Binding Myosin VI Binding Phosphatidylinositol Binding Phenotypic Switching Histone H3K56 Methyltransferase Activity Sperm Cytoplasmic Droplet Calpain Complex Protein Tyrosine Phosphatase Activator Activity Receptor-receptor Interaction Mammary Gland Involution Adult Behavior Chondroblast Differentiation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Endosome Organization Peptidyl-lysine Dimethylation
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