BBS9 and TOM1L2

Number of citations of the paper that reports this interaction (PubMedID 37019113)
80

Data Source:
BioGRID (pull down)

		BBS9	TOM1L2
Description		Bardet-Biedl syndrome 9	target of myb1 like 2 membrane trafficking protein
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Membrane	Endosome Membrane Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	Protein Binding Protein Kinase Binding Clathrin Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Visual Perception Protein Transport Cell Projection Organization Fat Cell Differentiation Cilium Assembly Protein Localization To Cilium	Signal Transduction Protein Transport Negative Regulation Of Mitotic Nuclear Division
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Asthma ( 29273806) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Disease progression in age-related macular degeneration ( 29346644) Intraocular pressure ( 29785010 31959993) Left–right brain asymmetry ( 33723403) Leprosy ( 27976721) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Metopic nonsyndromic craniosynostosis ( 32266521) Postoperative stroke after cardiac surgery ( 30678657) Sagittal craniosynostosis ( 23160099) Smooth-surface caries ( 24556642) Subcortical volume (MOSTest) ( 32665545) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)	Hip index ( 34021172) Schizophrenia ( 25056061 28991256 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Total body bone mineral density ( 29304378) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: TOM1 TOM1L2	15 interacting genes: APP BBS4 BBS5 BBS9 FAM9B LAPTM5 MAP3K1 MYO6 NEDD4 RNF11 RNF26 SMURF1 UBC WBP2 WWP2
Entrez ID		27241	146691
HPRD ID		16262	18213
Ensembl ID		ENSG00000122507	ENSG00000175662
Uniprot IDs		A0A090N7W2 A0A090N8P4 A0A5F9ZGY2 A0A5F9ZH14 A0A5F9ZH74 A0A5F9ZHE7 Q3SYG4	B7Z2U2 B7Z671 F5H3S6 Q6ZVM7
PDB IDs		4YD8 6XT9
Enriched GO Terms of Interacting Partners?		Regulation Of Macroautophagy Clathrin Binding Regulation Of Autophagy Negative Regulation Of Monocyte Activation Specific Granule Membrane Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Corticotropin Hormone Secreting Cell Differentiation Ubiquitin Binding Myosin VI Binding Phosphatidylinositol Binding Phenotypic Switching Histone H3K56 Methyltransferase Activity Sperm Cytoplasmic Droplet Calpain Complex Protein Tyrosine Phosphatase Activator Activity Receptor-receptor Interaction Mammary Gland Involution Adult Behavior Chondroblast Differentiation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Endosome Organization Peptidyl-lysine Dimethylation	BBSome Establishment Of Protein Localization Ciliary Membrane Modification-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Ubiquitin Protein Ligase Activity Potassium Channel Inhibitor Activity Protein Targeting To Vacuole Protein Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Transport Protein Localization To Vacuole Receptor Catabolic Process Establishment Of Melanosome Localization Pericentriolar Material Melanosome Transport Pigment Granule Transport Ubiquitin Ligase Complex Post-translational Protein Modification Protein Polyubiquitination Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Catabolic Process Pigment Granule Localization Melanosome Localization Ubiquitin-dependent Protein Catabolic Process Centriolar Satellite Intracellular Protein Localization Protein Targeting To Lysosome Negative Regulation Of Potassium Ion Transport Establishment Of Protein Localization To Organelle Ciliary Transition Zone Protein Localization To Organelle Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Minus-end Directed Microfilament Motor Activity Macromolecule Catabolic Process Vacuolar Transport Formation Of Structure Involved In A Symbiotic Process Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Engulfment Of Target By Autophagosome Fructose:sodium Symporter Activity
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