JPT1 and ARHGAP44

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		JPT1	ARHGAP44
Name		Jupiter microtubule associated homolog 1	Rho GTPase activating protein 44
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Cytoskeleton Intercellular Bridge	Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Dendrite Leading Edge Membrane Cell Projection Dendritic Spine Synapse Presynaptic Active Zone Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Phospholipid Binding Small GTPase Binding
	Biological Process	None	Exocytosis Signal Transduction Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Rac Protein Signal Transduction Regulation Of GTPase Activity Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Filopodium Assembly Regulation Of Dendritic Spine Morphogenesis Modification Of Postsynaptic Structure Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Pathways		None	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
GWAS		No GWAS studies recorded	Hip circumference adjusted for BMI ( 28552196 ) Joint mobility (Beighton score) ( 27182965 ) Multiple system atrophy (pathologically confirmed) ( 27629089 )
Interacting Genes		3 interacting genes: ARHGAP44 OTX2 SFPQ	4 interacting genes: CDC42 JPT1 RAC1 SHANK3
Entrez ID		51155	9912
HPRD ID		13665	13810
Ensembl ID		ENSG00000189159	ENSG00000006740
Uniprot IDs		Q9UK76	E7ERK8 Q17R89
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Primitive Streak Formation Eukaryotic Initiation Factor 4E Binding Positive Regulation Of Gastrulation Dendritic Transport Of Messenger Ribonucleoprotein Complex Dendrite Paraspeckles Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Circadian Rhythm Positive Regulation Of Sister Chromatid Cohesion Negative Regulation Of Filopodium Assembly Leading Edge Membrane Negative Regulation Of Rac Protein Signal Transduction Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Regulation Of Gastrulation Positive Regulation Of Embryonic Development Dendritic Transport Regulation Of Sister Chromatid Cohesion Modification Of Postsynaptic Structure Regulation Of Endocytic Recycling	G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Thioesterase Binding Regulation Of Postsynapse Organization Dendritic Spine Morphogenesis GTP-dependent Protein Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Cell Projection Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Actin Filament Organization Neuron Projection Morphogenesis Dendritic Spine Organization Phagocytosis, Engulfment Regulation Of Synapse Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Organization Regulation Of Actin Filament-based Process Postsynapse Organization Membrane Invagination Regulation Of Supramolecular Fiber Organization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Dendritic Spine Development Regulation Of Neuronal Synaptic Plasticity Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Junction Organization Positive Regulation Of Actin Filament Bundle Assembly Neuron Projection Development G Protein Activity Regulation Of Cytoskeleton Organization Cytoplasmic Ribonucleoprotein Granule Regulation Of Stress Fiber Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Cellular Component Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell-substrate Adhesion GBD Domain Binding Storage Vacuole Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Central Nervous System Neuron Differentiation Cerebral Cortex GABAergic Interneuron Development