ARHGAP44

Description		Rho GTPase activating protein 44
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Dendrite Leading Edge Membrane Cell Projection Dendritic Spine Synapse Presynaptic Active Zone Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Phospholipid Binding Small GTPase Binding
	Biological Process	Exocytosis Signal Transduction Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Rac Protein Signal Transduction Regulation Of GTPase Activity Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Filopodium Assembly Regulation Of Dendritic Spine Morphogenesis Modification Of Postsynaptic Structure Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Joint mobility (Beighton score) ( 27182965) Multiple system atrophy (pathologically confirmed) ( 27629089)
Interacting Genes		4 interacting genes: CDC42 JPT1 RAC1 SHANK3
Entrez ID		9912
HPRD ID		13810
Ensembl ID		ENSG00000006740
Uniprot IDs		E7ERK8 Q17R89
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Thioesterase Binding Regulation Of Postsynapse Organization Dendritic Spine Morphogenesis GTP-dependent Protein Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Cell Projection Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Actin Filament Organization Neuron Projection Morphogenesis Dendritic Spine Organization Phagocytosis, Engulfment Regulation Of Synapse Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Organization Regulation Of Actin Filament-based Process Postsynapse Organization Membrane Invagination Regulation Of Supramolecular Fiber Organization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Dendritic Spine Development Regulation Of Neuronal Synaptic Plasticity Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Junction Organization Positive Regulation Of Actin Filament Bundle Assembly Neuron Projection Development G Protein Activity Regulation Of Cytoskeleton Organization Cytoplasmic Ribonucleoprotein Granule Regulation Of Stress Fiber Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Cellular Component Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell-substrate Adhesion GBD Domain Binding Storage Vacuole Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Central Nervous System Neuron Differentiation Cerebral Cortex GABAergic Interneuron Development
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