COMMD2 and COMMD1

Number of citations of the paper that reports this interaction (PMID 15799966)
52

Data Source:
HPRD (in vitro)

		COMMD2	COMMD1
Gene Name		COMM domain containing 2	copper metabolism (Murr1) domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Early Endosome Cul2-RING Ubiquitin Ligase Complex Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process		Golgi To Plasma Membrane Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: APP COMMD1	27 interactors: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 KAT2A LIG4 NFKBIA RELA SLC12A2 SOCS1 SPP1 TCEB1 XIAP
Entrez ID		51122	150684
HPRD ID		13081	06253
Ensembl ID		ENSG00000114744
Uniprot IDs		Q86X83	Q8N668
PDB IDs			2H2M
Enriched GO Terms of Interacting Partners?		Copper Ion Homeostasis Transition Metal Ion Homeostasis Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Metal Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Ion Homeostasis Plasma Membrane To Endosome Transport Negative Regulation Of Protein Localization To Cell Surface Neuron Remodeling Regulation Of Proteolysis Negative Regulation Of Sodium Ion Transport Chemical Homeostasis Cellular Copper Ion Homeostasis Regulation Of Protein Localization To Cell Surface Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Metabolic Process Mating Behavior Golgi To Plasma Membrane Transport Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Sodium Ion Transmembrane Transport Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Homeostatic Process Ionotropic Glutamate Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Ion Transmembrane Transport Intracellular Transport Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Transmembrane Transport Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway	Protein Ubiquitination Protein Modification By Small Protein Conjugation Viral Process Intrinsic Apoptotic Signaling Pathway Cell Cycle Arrest Ubiquitin-dependent Protein Catabolic Process Response To Stress Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Stress Apoptotic Signaling Pathway Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Cell Cycle Cellular Response To Stimulus Apoptotic Process Cell Cycle Negative Regulation Of Cell Cycle Programmed Cell Death Cell Death Death Response To Abiotic Stimulus Regulation Of Cell Proliferation G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Process Intracellular Signal Transduction Cell Cycle Process Response To Stimulus Proteolysis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Modification Process Regulation Of Metabolic Process Protein Monoubiquitination Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Phase Transition Protein K6-linked Ubiquitination Mitotic Cell Cycle Process Negative Regulation Of NF-kappaB Transcription Factor Activity Protein Metabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process
Tagcloud ?			beneficial cart comparative considering edged eradication hiv ikappab infected innate jak latency latent lymphoid murr1 parental poses proteasomal reactivation reinforcing respective restriction retroviral sets stabilized suppressing sword tnfalpha toll
Tagcloud (Difference) ?			beneficial cart comparative considering edged eradication hiv ikappab infected innate jak latency latent lymphoid murr1 parental poses proteasomal reactivation reinforcing respective restriction retroviral sets stabilized suppressing sword tnfalpha toll
Tagcloud (Intersection) ?