TFB1M and VEGFB

		TFB1M	VEGFB
Description		transcription factor B1, mitochondrial	vascular endothelial growth factor B
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	RRNA (adenine-N6,N6-)-dimethyltransferase Activity DNA Binding RNA Binding Protein Binding Methyltransferase Activity Transferase Activity Mitochondrial Transcription Factor Activity S-adenosyl-L-methionine Binding	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 1 Binding Receptor Ligand Activity
	Biological Process	RRNA Modification RRNA Processing Transcription Initiation At Mitochondrial Promoter RRNA Methylation Methylation	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Protein O-linked Glycosylation Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Vascular Wound Healing Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Transcriptional activation of mitochondrial biogenesis rRNA modification in the mitochondrion	Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs			Aflibercept
Diseases			Gastric cancer
GWAS		Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Metabolite levels ( 23823483) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Crohn's disease ( 28067908) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Red blood cell count ( 32888494) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		2 interacting genes: POLRMT TFAM	6 interacting genes: ADRB2 FLT1 KLHL12 NRP1 TNXB VEGFA
Entrez ID		51106	7423
HPRD ID		09515	03237
Ensembl ID		ENSG00000029639	ENSG00000173511
Uniprot IDs		E5KTM5 Q8WVM0	P49765 Q7LAP4
PDB IDs		6AAX 6AJK 8CSP 8CSQ 8CSR 8CSU	2C7W 2VWE 2XAC 6TKK
Enriched GO Terms of Interacting Partners?		Mitochondrial Promoter Sequence-specific DNA Binding Transcription Initiation At Mitochondrial Promoter Mitochondrial Transcription Mitochondrial Nucleoid Mitochondrial RNA Metabolic Process DNA-templated Transcription Initiation Mitochondrial DNA-directed RNA Polymerase Complex Macromolecule Biosynthetic Process Mitochondrial Transcription Factor Activity Vascular Endothelial Growth Factor Receptor 1 Binding Vascular Endothelial Growth Factor Receptor Binding Response To Decreased Oxygen Levels Response To Hypoxia Positive Regulation Of Vascular Wound Healing Positive Regulation Of Mast Cell Chemotaxis Response To Oxygen Levels 5'-3' RNA Polymerase Activity Regulation Of Mast Cell Chemotaxis Mitochondrial Matrix DNA-templated Transcription Mitochondrial DNA Replication Sequence-specific DNA Binding Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Wound Healing Induction Of Positive Chemotaxis Positive Regulation Of Vascular Permeability Mitochondrial DNA Metabolic Process Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Positive Chemotaxis Coronary Vasculature Development DNA-directed RNA Polymerase Activity 3'-5'-RNA Exonuclease Activity Protein-containing Complex Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemoattractant Activity DNA-directed RNA Polymerase Complex Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Cardiac Muscle Contraction Positive Chemotaxis Regulation Of Vascular Permeability DNA-templated DNA Replication Transcription Coactivator Binding Positive Regulation Of Peptidyl-tyrosine Phosphorylation Heat Shock Protein Binding Positive Regulation Of Wound Healing Platelet Alpha Granule Lumen	Adaptive Thermogenesis Vascular Endothelial Growth Factor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Cold Neuropilin Signaling Pathway Oxidative Phosphorylation Uncoupler Activity Response To Superoxide Positive Regulation Of Axon Extension Involved In Axon Guidance Vascular Endothelial Growth Factor Receptor Activity Response To Oxygen Radical Coronary Artery Morphogenesis Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Regulation Of MAPK Cascade Positive Regulation Of Cold-induced Thermogenesis Blood Vessel Morphogenesis Commissural Neuron Axon Guidance Motor Neuron Migration Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Locomotion Mitochondrial Transmembrane Transport Retinal Ganglion Cell Axon Guidance Regulation Of Cold-induced Thermogenesis Response To Temperature Stimulus Regulation Of Endothelial Cell Proliferation Proton Transmembrane Transporter Activity Cell Migration Involved In Sprouting Angiogenesis Heparin Binding Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Branching Involved In Blood Vessel Morphogenesis Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Receptor Complex Mitochondrial Transport Platelet-derived Growth Factor Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Cell Chemotaxis Positive Regulation Of Axon Extension Growth Factor Binding
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