CRYL1 and ABCC6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CRYL1	ABCC6
Gene Name		crystallin, lambda 1	ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane
	Molecular Function	3-hydroxyacyl-CoA Dehydrogenase Activity Protein Homodimerization Activity L-gulonate 3-dehydrogenase Activity NAD+ Binding	Transporter Activity ATP Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Fatty Acid Metabolic Process Oxidation-reduction Process	Transport Visual Perception Response To Drug Transmembrane Transport
Pathways			ABC-family proteins mediated transport
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Obesity-related traits ( 23251661)
Protein-Protein Interactions		1 interactors: ABCC6	5 interactors: A1BG AK2 CRYL1 FURIN NR4A1
Entrez ID		51084	368
HPRD ID		16762	04453
Ensembl ID		ENSG00000165475	ENSG00000091262
Uniprot IDs		Q9Y2S2	A2RRN8 O95255
PDB IDs		3F3S
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production ADP Biosynthetic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity DATP Metabolic Process Negative Regulation Of Proteolysis Nucleoside Diphosphate Biosynthetic Process Viral Protein Processing Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing ADP Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Regulation Of Peptidase Activity AMP Metabolic Process Endothelial Cell Chemotaxis Response To Thyroid Hormone Nucleobase-containing Small Molecule Interconversion Signal Peptide Processing Cell Migration Involved In Sprouting Angiogenesis Virion Assembly Deoxyribonucleoside Triphosphate Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptide Biosynthetic Process Blood Vessel Endothelial Cell Migration Regulation Of Proteolysis Peptide Hormone Processing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Catalytic Activity Response To Organic Substance
Tagcloud ?			alpl bmp2 bmps calcification comes ectonucleotides elasticum enpp1 extrapolate localizing mineralisation mineralization msx2 multisystem neovascularisation osteoinductive papular perturbed pseudoxanthoma pxe runx2 smad2 smads stains subretinal tgfbeta tgfbeta1 tgfbetas whiskers
Tagcloud (Difference) ?			alpl bmp2 bmps calcification comes ectonucleotides elasticum enpp1 extrapolate localizing mineralisation mineralization msx2 multisystem neovascularisation osteoinductive papular perturbed pseudoxanthoma pxe runx2 smad2 smads stains subretinal tgfbeta tgfbeta1 tgfbetas whiskers
Tagcloud (Intersection) ?