MTERF3 and ZDHHC21

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MTERF3	ZDHHC21
Name		mitochondrial transcription termination factor 3	zDHHC palmitoyltransferase 21
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding Nucleic Acid Binding DNA Binding Protein Binding	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Ribosome Biogenesis Negative Regulation Of DNA-templated Transcription Mitochondrial Ribosome Assembly Regulation Of Mitochondrial Transcription	Hair Follicle Development Regulation Of Vascular Associated Smooth Muscle Contraction Protein Targeting To Membrane Peptidyl-L-cysteine S-palmitoylation Nitric Oxide Metabolic Process Sebaceous Gland Development Adrenergic Receptor Signaling Pathway Regulation Of Establishment Of Endothelial Barrier Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Pathways		PINK1-PRKN Mediated Mitophagy rRNA modification in the mitochondrion Mitochondrial mRNA modification	eNOS activation Extra-nuclear estrogen signaling
GWAS		No GWAS studies recorded	Age at first sexual intercourse ( 34211149 ) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697 ) Hypothyroidism ( 22493691 ) Metabolite levels ( 23823483 ) Neuritic plaque ( 31497858 ) Schizophrenia ( 33169155 ) Visceral adipose tissue adjusted for BMI ( 22589738 )
Interacting Genes		28 interacting genes: ADGRE2 AGTRAP APOC1 APP ARL6IP1 CACFD1 CMTM5 ERG28 FADS6 FUNDC1 GPR108 HIGD1C MAL2 MIR34B PBX3 RHBDD2 SCAMP1 SLC17A9 SLC2A5 SLC50A1 STX8 SYNGR1 SYP TMEM14C UPF2 YIF1A ZDHHC21 ZFPL1	12 interacting genes: AQP6 CHODL CREB3 ELOVL4 ERGIC3 FAM210B MTERF3 MUC1 PGRMC2 RNASEK TMEM167B TRIM59
Entrez ID		51001	340481
HPRD ID		10823	15716
Ensembl ID		ENSG00000156469	ENSG00000175893
Uniprot IDs		E5RIK9 Q96E29	Q8IVQ6
PDB IDs		3M66	Not available
GO Terms Enriched among Interactors		Membrane Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Apparatus Regulation Of Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Endoplasmic Reticulum Very-low-density Lipoprotein Particle Vesicle-mediated Transport Golgi Membrane	None