NSDHL and RHBDD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NSDHL	RHBDD1
Description		NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL	rhomboid domain containing 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	3-beta-hydroxysteroid Dehydrogenase [NAD(P)+]/C4-decarboxylase Activity 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 3-beta-hydroxysteroid Dehydrogenase (NAD+)/C4-decarboxylase Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Hair Follicle Development Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Smoothened Signaling Pathway Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process Labyrinthine Layer Blood Vessel Development	Proteolysis Apoptotic Process Spermatogenesis Positive Regulation Of Protein Processing Cell Differentiation Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Spermatid Differentiation Positive Regulation Of Secretion Positive Regulation Of Protein Metabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation
Pathways		Cholesterol biosynthesis Cholesterol biosynthesis via lathosterol
Drugs		NADH
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)
GWAS		Glycated hemoglobin levels ( 34059833)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Kawasaki disease ( 33692975) Pulmonary function ( 17903307)
Interacting Genes		5 interacting genes: ERG28 GPR35 RHBDD1 TMEM31 TMX2	21 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC ITCH LPCAT2 LRRK2 MFHAS1 NEDD4 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TGFA TMEM42 TMEM86B TMIE
Entrez ID		50814	84236
HPRD ID		02229	13206
Ensembl ID		ENSG00000147383	ENSG00000144468
Uniprot IDs		A0A384NPZ7 Q15738	Q8TEB9
PDB IDs		6JKG 6JKH	5EPP
Enriched GO Terms of Interacting Partners?			Regulation Of Autophagy Negative Regulation Of Autophagy Endoplasmic Reticulum Membrane Regulation Of Autophagosome Assembly Endoplasmic Reticulum Regulation Of Vacuole Organization Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Negative Regulation Of Autophagosome Assembly Positive Regulation Of Protein Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Membrane Syntaxin-1 Binding Ubiquitin-protein Transferase Activity Ether Lipid Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Neuromuscular Junction Development Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of Catabolic Process Negative Regulation Of Macroautophagy 3-beta-hydroxysteroid Dehydrogenase [NAD(P)+]/C4-decarboxylase Activity 3-beta-hydroxysteroid Dehydrogenase (NAD+)/C4-decarboxylase Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly D-lysine 5,6-aminomutase Activity Channel Inhibitor Activity Regulation Of Macroautophagy Protein Monoubiquitination Lumenal Side Of Lysosomal Membrane ER To Golgi Transport Vesicle Membrane Regulation Of Macrophage Activation Plasmalogen Synthase Activity Organelle Subcompartment Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity
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