SLC45A1 and NPPB

		SLC45A1	NPPB
Description		solute carrier family 45 member 1	natriuretic peptide B
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex
	Molecular Function	D-glucose:proton Symporter Activity Sucrose:proton Symporter Activity Symporter Activity Galactose:proton Symporter Activity Transmembrane Transporter Activity	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding
	Biological Process	Galactose Transmembrane Transport Sucrose Transport Transmembrane Transport D-glucose Transmembrane Transport	System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Killing Of Cells Of Another Organism Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Regulation Of Vascular Permeability Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance
Pathways
Drugs			Carvedilol Oxymetholone
Diseases
GWAS		Allergic rhinitis ( 30013184) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 23468962) Brown vs. black hair color ( 30531825) Depression ( 29700475) Fish- and plant-related diet ( 32066663) Hair color ( 29662168) Hair shape ( 29220522) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hippocampal volume in normal cognition ( 29274321) Inflammatory skin disease ( 25574825) Morning person ( 30696823) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Psoriasis ( 25903422 23143594) Schizophrenia ( 29483656 28991256) Strep throat ( 28928442) Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan) ( 28521775) Youthful appearance (self-reported) ( 32339537)	B-type natriuretic peptide levels ( 25561047 29237677) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677) Blood pressure ( 21909110) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Diastolic blood pressure ( 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip index ( 34021172) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) N-terminal pro B-type natriuretic peptide levels ( 29237677) NT-proBNP levels in acute coronary syndrome ( 26908625) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 28739976 27618452 27618447 19430483) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		1 interacting genes: PPP1CA	13 interacting genes: CYSRT1 EWSR1 GEMIN4 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NLA NPR1 NPR2 NPR3 PSMA3 SERTAD3
Entrez ID		50651	4879
HPRD ID		19078	08974
Ensembl ID		ENSG00000162426	ENSG00000120937
Uniprot IDs		Q9Y2W3	P16860
PDB IDs			1YK1 3N56
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Tissue Development Positive Regulation Of Pentose-phosphate Shunt Positive Regulation Of Cytoplasmic Translational Initiation Cellular Response To Oxygen Levels Energy Reserve Metabolic Process Regulation Of Growth Regulation Of Circadian Rhythm TORC1 Complex Generation Of Precursor Metabolites And Energy Regulation Of Membrane Permeability Inositol Hexakisphosphate Binding Response To Temperature Stimulus RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding Cellular Response To Decreased Oxygen Levels Regulation Of Locomotor Rhythm Nucleobase-containing Small Molecule Metabolic Process Regulation Of Carbohydrate Catabolic Process Calcium-mediated Signaling Cellular Response To Hypoxia Energy Derivation By Oxidation Of Organic Compounds Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade TFIIIC-class Transcription Factor Complex Binding Regulation Of Pentose-phosphate Shunt RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Positive Regulation Of Cell Growth Striated Muscle Tissue Development Negative Regulation Of TORC2 Signaling Cellular Response To Insulin Stimulus Muscle Tissue Development Regulation Of Stress Fiber Assembly Positive Regulation Of Small Molecule Metabolic Process Regulation Of Calcium-mediated Signaling Cellular Response To Methionine Voluntary Musculoskeletal Movement 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Response To Insulin Small Molecule Metabolic Process Negative Regulation Of Lysosome Organization Regulation Of Translational Initiation Regulation Of Cell Growth T-helper 1 Cell Lineage Commitment RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Purine Ribonucleotide Biosynthetic Process Hormone Receptor Binding Ribose Phosphate Biosynthetic Process Regulation Of Blood Pressure	Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Keratin Filament Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase I Neuronal Action Potential Ribose Phosphate Biosynthetic Process Intermediate Filament Regulation Of Cell Growth Negative Regulation Of Cell Growth Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process G Protein-coupled Peptide Receptor Activity Regulation Of Myotube Differentiation Regulation Of Transcription By RNA Polymerase I Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Blood Circulation Nucleotide Biosynthetic Process ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Blood Vessel Remodeling D-glucose:proton Symporter Activity Galactose:proton Symporter Activity Regulation Of Glycolytic Process Negative Regulation Of Growth Purine-containing Compound Biosynthetic Process Cajal Body Regulation Of Locomotor Rhythm Regulation Of Carbohydrate Catabolic Process TFIIIC-class Transcription Factor Complex Binding Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Sucrose Transport Sucrose:proton Symporter Activity Nucleobase-containing Small Molecule Metabolic Process Regulation Of ATP Metabolic Process
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