G0S2 and RNF126

Number of citations of the paper that reports this interaction (PubMedID 31371451)
29

Data Source:
BioGRID (enzymatic study)

		G0S2	RNF126
Description		G0/G1 switch 2	ring finger protein 126
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Lipid Droplet	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		PPARA activates gene expression	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)
Interacting Genes		4 interacting genes: BCL2L1 BCL2L2 RNF126 RPL30	42 interacting genes: ABCG2 AICDA BAG6 CENPP CSNK2B E2F1 EGFR FXN G0S2 HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SFN SNUPN TARDBP TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6
Entrez ID		50486	55658
HPRD ID		09968	11501
Ensembl ID		ENSG00000123689	ENSG00000070423
Uniprot IDs		P27469	A8K0Q1 Q9BV68
PDB IDs			2N9O 2N9P
Enriched GO Terms of Interacting Partners?		Bcl-2 Family Protein Complex Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Process In Bone Marrow Cell Extrinsic Apoptotic Signaling Pathway DNA Damage Response Epithelial Cell Proliferation Mitochondrial Membrane Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Mitochondrial Outer Membrane Cytoplasm Protein Quality Control Response To Cycloheximide Response To Stress Mitochondrion Organization BH3 Domain Binding Sertoli Cell Proliferation Negative Regulation Of Dendritic Cell Apoptotic Process Apoptotic Signaling Pathway Negative Regulation Of Execution Phase Of Apoptosis Cellular Response To Stress Protein K29-linked Ubiquitination DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Male Gamete Generation Hepatocyte Apoptotic Process Negative Regulation Of Mitochondrial Membrane Permeability Spermatogenesis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Release Of Cytochrome C From Mitochondria Ectopic Germ Cell Programmed Cell Death Negative Regulation Of Membrane Permeability Negative Regulation Of Anoikis Protein K27-linked Ubiquitination Programmed Cell Death Involved In Cell Development Regulation Of Cellular Response To Stress Gamete Generation Positive Regulation Of Apoptotic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Anoikis Disordered Domain Specific Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Cytosol Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Damage Response Protein K11-linked Ubiquitination Nucleus Negative Regulation Of Metabolic Process Ubiquitin Binding Transferase Activity Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K63-linked Ubiquitination Catabolic Process Protein-containing Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Nucleoplasm Cellular Response To Stress Regulation Of Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Protein Catabolic Process Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process
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