ATP2A3 and CDH16

Data Source: HiPPIP (Novel)

		ATP2A3	CDH16
Name		ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	cadherin 16
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Organelle Membrane Platelet Dense Tubular Network Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane	Plasma Membrane Membrane Basolateral Plasma Membrane Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Calcium Channel Regulator Activity P-type Calcium Transporter Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Calcium-dependent ATPase Activity Transmembrane Transporter Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Transport Across Blood-brain Barrier Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell-cell Adhesion
Pathways		Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Diastolic blood pressure ( 27841878 ) Glucose homeostasis traits ( 25524916 ) Lung function (FEV1/FVC) ( 30804560 ) Metabolite levels ( 23823483 ) Mild age-related type 2 diabetes ( 34737425 ) Peak expiratory flow ( 30804560 ) Refractive error ( 32231278 )	HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Novel Interactors		2 novel interactors: CDH16 MTCH1	7 novel interactors: ATP2A3 CDH5 GCM1 MRPL52 NDUFS8 NQO1 TUBB
Interacting Genes		1 interacting genes: IRS1	2 interacting genes: CTNNB1 G6PC1
Entrez ID		489	1014
HPRD ID		03568	11929
Ensembl ID		ENSG00000074370	ENSG00000166589
Uniprot IDs		A8K9K1 Q93084	O75309
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Negative Regulation Of Insulin Secretion Regulation Of Fatty Acid Beta-oxidation Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Binding Negative Regulation Of Cellular Response To Insulin Stimulus SH2 Domain Binding Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Insulin Receptor Complex Cellular Response To Fatty Acid Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Peptide Secretion Positive Regulation Of D-glucose Import Protein Kinase C Binding Regulation Of Fatty Acid Oxidation Positive Regulation Of Fatty Acid Beta-oxidation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Transmembrane Transport Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Positive Regulation Of Fatty Acid Oxidation Regulation Of Glycogen Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Neuronal Ion Channel Clustering Membrane Insertase Activity Protein Insertion Into Mitochondrial Outer Membrane Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Response To Fatty Acid Regulation Of Lipid Catabolic Process Regulation Of D-glucose Import	Response To Caloric Restriction Transmembrane Transporter Binding Catenin Complex Homeostatic Process Calcium-dependent ATPase Activity Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Endothelial Cell Differentiation Cell Periphery Cell-cell Junction Assembly Protein Phosphatase Binding Cell-cell Adhesion Mediated By Cadherin Adherens Junction Organization Bicellular Tight Junction Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Catenin-TCF7L2 Complex NADH Dehydrogenase (quinone) (non-electrogenic) Activity NADPH Dehydrogenase (quinone) Activity NAD(P)H Dehydrogenase (quinone) Activity Response To Resveratrol Glucose-6-phosphatase Activity Astrocyte Fate Commitment