ATP2A3

Description		ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Organelle Membrane Platelet Dense Tubular Network Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	Nucleotide Binding Calcium Channel Regulator Activity P-type Calcium Transporter Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Calcium-dependent ATPase Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Transport Across Blood-brain Barrier Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction
Pathways		Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Diastolic blood pressure ( 27841878) Glucose homeostasis traits ( 25524916) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Mild age-related type 2 diabetes ( 34737425) Peak expiratory flow ( 30804560) Refractive error ( 32231278)
Novel Interacting Genes		2 novel interacting genes: CDH16 MTCH1
Interacting Genes		1 interacting genes: IRS1
Entrez ID		489
HPRD ID		03568
Ensembl ID		ENSG00000074370
Uniprot IDs		A8K9K1 Q93084
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Negative Regulation Of Insulin Secretion Regulation Of Fatty Acid Beta-oxidation Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Binding Negative Regulation Of Cellular Response To Insulin Stimulus SH2 Domain Binding Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Insulin Receptor Complex Cellular Response To Fatty Acid Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Peptide Secretion Positive Regulation Of D-glucose Import Protein Kinase C Binding Regulation Of Fatty Acid Oxidation Positive Regulation Of Fatty Acid Beta-oxidation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Transmembrane Transport Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Positive Regulation Of Fatty Acid Oxidation Regulation Of Glycogen Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Neuronal Ion Channel Clustering Membrane Insertase Activity Protein Insertion Into Mitochondrial Outer Membrane Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Response To Fatty Acid Regulation Of Lipid Catabolic Process Regulation Of D-glucose Import
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