CNOT3 and ID3

Number of citations: 0 (PubMedID 18255255)
Data Source: BioGRID (two hybrid)

		CNOT3	ID3
Name		CCR4-NOT transcription complex subunit 3	inhibitor of DNA binding 3
Structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Protein Dimerization Activity Transcription Regulator Inhibitor Activity Leptomycin B Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Cold-induced Thermogenesis Regulation Of Stem Cell Population Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Regulation Of DNA Replication Central Nervous System Development Heart Development Muscle Organ Development Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Neuron Differentiation Epithelial Cell Differentiation Notochord Development Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Leptomycin B
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	NGF-stimulated transcription
GWAS		PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: CAND1 CAND2 CNOT1 CNOT2 CNOT4 CNOT8 CREBBP ID3 OBI1 RUNX1	49 interacting genes: ADD1 ANKS1A ATF3 BOLA2 BOLA2B C22orf39 CBFA2T2 CDK2 CNOT3 CREB5 CSK E2F4 ELK1 ELK4 FAM74A1 FHL2 FRS3 GATA4 GNB2 GTF2A1L GUCD1 HES1 HOXA1 ID4 IFI16 IKBKG KAT5 KRTAP26-1 LMO4 MLX MSGN1 MYF5 MYF6 MYOD1 MYOG PAX5 PRDM14 PUF60 RND1 RUNX1T1 SAP30 SDCBP SREBF1 TCF12 TCF3 TCF4 ZNF3 ZNF408 ZNF626
Entrez ID		4849	3399
HPRD ID		05368	02608
Ensembl ID		ENSG00000088038	ENSG00000117318
Uniprot IDs		O75175	Q02535
PDB IDs		4C0D 4C0G 5FU6 5FU7 9C3H 9C3I	2LFH
GO Terms Enriched among Interactors		CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Poly(A)-specific Ribonuclease Activity Nuclear-transcribed MRNA Catabolic Process SCF Complex Assembly MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly P-body Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleobase-containing Compound Catabolic Process Trophectodermal Cell Differentiation Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Negative Regulation Of Macromolecule Biosynthetic Process TBP-class Protein Binding Negative Regulation Of Biosynthetic Process Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Transcription Corepressor Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression MRNA Metabolic Process Protein Ubiquitination Transcription Coactivator Binding Negative Regulation Of Metabolic Process Cellular Response To Leptomycin B Leptomycin B Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Autoubiquitination Regulation Of Stem Cell Population Maintenance Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding E-box Binding Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Cellular Developmental Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Skeletal Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Nucleoplasm Positive Regulation Of Metabolic Process Transcription Regulator Complex Cell Fate Commitment Negative Regulation Of Macromolecule Biosynthetic Process Muscle Cell Fate Commitment Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development