NFATC3 and CELSR2

		NFATC3	CELSR2
Description		nuclear factor of activated T cells 3	cadherin EGF LAG seven-pass G-type receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Cytoplasm Plasma Membrane Adherens Junction Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Calcineurin-NFAT Signaling Cascade Positive Thymic T Cell Selection Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription DN4 Thymocyte Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Artery Morphogenesis	Cilium Movement Regulation Of DNA-templated Transcription Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Axonogenesis Anterior/posterior Pattern Specification Wnt Signaling Pathway Ventricular System Development Neural Plate Anterior/posterior Regionalization Regulation Of Cell-cell Adhesion Regulation Of Protein Localization Cerebrospinal Fluid Secretion Cell-cell Adhesion Mediated By Cadherin Animal Organ Development Dendrite Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Cilium Assembly Motor Neuron Migration Plasma Membrane Bounded Cell Projection Organization
Pathways		Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation
Drugs
Diseases
GWAS		Chronotype ( 30696823) Estimated glomerular filtration rate ( 31015462) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528)	Abdominal aortic aneurysm ( 27899403) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565 28270201 26780889 25961943 24886709) Coronary artery disease ( 29212778 33020668) Coronary heart disease ( 21378988) HDL cholesterol ( 30275531 25961943) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531 18193043 26780889 20686565 20864672 19060911 19060910 21347282 19060906 18262040 18193044 25961943 18179892) LDL cholesterol levels ( 32203549 30698716 31087446) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 19936222) Lipoprotein (a) levels ( 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease ( 28753643) Low density lipoprotein cholesterol levels ( 30911093 33339817 29403010 32902719 32154731 30718733) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 21909109) Myocardial infarction ( 33532862) Myocardial infarction (early onset) ( 19198609) Non-HDL cholesterol levels ( 32902719) Parental lifespan ( 30642433) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Response to statin therapy ( 20339536) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30275531 32902719 29403010 30911093 33339817 30718733)
Interacting Genes		7 interacting genes: CDK6 CSNK1A1 FOS IGF2BP3 MAPK8 MAPK9 TTF1	3 interacting genes: GARS1 KLF6 PHF10
Entrez ID		4775	1952
HPRD ID		04077	05040
Ensembl ID		ENSG00000072736	ENSG00000143126
Uniprot IDs		B5B2S0 B5B2S1 Q12968	Q9HCU4
PDB IDs		2XRW 2XS0
Enriched GO Terms of Interacting Partners?		JUN Kinase Activity Parallel Fiber To Purkinje Cell Synapse Protein Serine Kinase Activity NLRP3 Inflammasome Complex Assembly Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway MAP Kinase Activity Protein Serine/threonine Kinase Activity R-SMAD Binding Response To Reactive Oxygen Species Positive Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Protein Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Oxidative Stress Regulation Of MRNA Stability Regulation Of RNA Stability Cyclin D2-CDK6 Complex Medium-term Memory Cellular Response To Prolactin JUN Phosphorylation Positive Regulation Of MiRNA Transcription Fc Receptor Signaling Pathway Cellular Response To Nutrient Levels JNK Cascade Kinase Activity Positive Regulation Of MiRNA Metabolic Process Cellular Response To Chemical Stress Cellular Senescence Dendriole Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding I(KACh) Inward Rectifier Potassium Channel Complex Protein Localization To Tricellular Tight Junction Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of MiRNA Transcription Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Neural Plate Anterior/posterior Regionalization Response To Prolactin Conditioned Taste Aversion Regulation Of MiRNA Metabolic Process Regulation Of MRNA Metabolic Process Termination Of RNA Polymerase I Transcription Regulation Of Cell Growth By Extracellular Stimulus Protein Phosphorylation	Glycyl-tRNA Aminoacylation Mitochondrial Glycyl-tRNA Aminoacylation Glycine-tRNA Ligase Activity ATP:ATP Adenylyltransferase Activity Diadenosine Tetraphosphate Biosynthetic Process DN4 Thymocyte Differentiation Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Chromatin Lymphocyte Differentiation Positive Regulation Of Artery Morphogenesis Mononuclear Cell Differentiation TRNA Aminoacylation For Mitochondrial Protein Translation Regulation Of Artery Morphogenesis Leukocyte Differentiation Positive Thymic T Cell Selection Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive T Cell Selection RSC-type Complex NpBAF Complex Lymphocyte Activation Thymic T Cell Selection Negative Regulation Of Smooth Muscle Cell Differentiation Calcineurin-NFAT Signaling Cascade Leukocyte Activation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of MiRNA Transcription T Cell Selection Calcineurin-mediated Signaling Regulation Of Nucleotide-excision Repair SWI/SNF Complex Histone Acetyltransferase Activity
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