NFATC3 and SEC24A

		NFATC3	SEC24A
Description		nuclear factor of activated T cells 3	SEC24 homolog A, COPII component
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Endoplasmic Reticulum Exit Site
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	SNARE Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Calcineurin-NFAT Signaling Cascade Positive Thymic T Cell Selection Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription DN4 Thymocyte Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Artery Morphogenesis	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Regulation Of Cholesterol Transport Cholesterol Homeostasis Positive Regulation Of Protein Secretion COPII-coated Vesicle Cargo Loading
Pathways		Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation	Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
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Diseases
GWAS		Chronotype ( 30696823) Estimated glomerular filtration rate ( 31015462) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: CDK6 CSNK1A1 FOS IGF2BP3 MAPK8 MAPK9 TTF1	7 interacting genes: ARID5A CBFA2T3 EWSR1 PEF1 TFG TRIP13 USP54
Entrez ID		4775	10802
HPRD ID		04077	08456
Ensembl ID		ENSG00000072736	ENSG00000113615
Uniprot IDs		B5B2S0 B5B2S1 Q12968	B4E205 O95486
PDB IDs		2XRW 2XS0	2NUP 2NUT 3EGD 3EGX 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO 8HR0
Enriched GO Terms of Interacting Partners?		JUN Kinase Activity Parallel Fiber To Purkinje Cell Synapse Protein Serine Kinase Activity NLRP3 Inflammasome Complex Assembly Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway MAP Kinase Activity Protein Serine/threonine Kinase Activity R-SMAD Binding Response To Reactive Oxygen Species Positive Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Protein Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Oxidative Stress Regulation Of MRNA Stability Regulation Of RNA Stability Cyclin D2-CDK6 Complex Medium-term Memory Cellular Response To Prolactin JUN Phosphorylation Positive Regulation Of MiRNA Transcription Fc Receptor Signaling Pathway Cellular Response To Nutrient Levels JNK Cascade Kinase Activity Positive Regulation Of MiRNA Metabolic Process Cellular Response To Chemical Stress Cellular Senescence Dendriole Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding I(KACh) Inward Rectifier Potassium Channel Complex Protein Localization To Tricellular Tight Junction Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of MiRNA Transcription Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Neural Plate Anterior/posterior Regionalization Response To Prolactin Conditioned Taste Aversion Regulation Of MiRNA Metabolic Process Regulation Of MRNA Metabolic Process Termination Of RNA Polymerase I Transcription Regulation Of Cell Growth By Extracellular Stimulus Protein Phosphorylation	COPII Vesicle Coating Vesicle Coating
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