NEO1 and NTN1

Number of citations of the paper that reports this interaction (PubMedID 8861902)
0

Data Source:
HPRD (in vitro, in vivo)

		NEO1	NTN1
Description		neogenin 1	netrin 1
Image
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Plasma Membrane Cell Surface Membrane Growth Cone Intracellular Vesicle Plasma Membrane Protein Complex Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Basement Membrane Nucleoplasm Cytoplasm Cytosol Actin Cytoskeleton Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Signaling Receptor Activity Co-receptor Binding Cadherin Binding BMP Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Neuron Migration Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Cell Adhesion Axon Guidance Myoblast Fusion Protein Secretion Positive Regulation Of BMP Signaling Pathway Regulation Of Axon Regeneration Negative Regulation Of Axon Regeneration Negative Regulation Of Protein Secretion Multicellular Organismal-level Iron Ion Homeostasis Cell-cell Adhesion Trans-synaptic Signaling, Modulating Synaptic Transmission	Neuron Migration Regulation Of Transcription By RNA Polymerase II Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Axonogenesis Axon Guidance Cell Population Proliferation Glial Cell Proliferation Regulation Of Cell Migration Negative Regulation Of Axon Extension Mammary Gland Development Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Positive Regulation Of Glial Cell Proliferation Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Motor Neuron Migration Cell-cell Adhesion Regulation Of Glial Cell Migration Positive Regulation Of Cell Motility
Pathways		Netrin-1 signaling Myogenesis	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Dentures ( 31235808) Face memory ( 31596458) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Red cell distribution width ( 32888494) Resting heart rate ( 27798624) Urate levels ( 31578528)	Appendicular lean mass ( 33097823) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 28869591 30598549) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Orofacial clefts ( 33137956) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)
Interacting Genes		6 interacting genes: MTDH NTN1 NTN3 PITPNA PTK2 TTN	5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		4756	9423
HPRD ID		03549	03368
Ensembl ID		ENSG00000067141	ENSG00000065320
Uniprot IDs		Q59FP8 Q92859	O95631
PDB IDs		1X5F 1X5G 1X5H 1X5I 1X5J 1X5K 3P4L	4URT 6FKQ 7NDG 7NE0 7NE1
Enriched GO Terms of Interacting Partners?		Detection Of Muscle Stretch Axon Guidance Axonogenesis Neuron Projection Guidance Anatomical Structure Morphogenesis Response To Muscle Stretch Neuron Projection Morphogenesis Cell Projection Morphogenesis Detection Of Mechanical Stimulus Cell Projection Organization Neuron Projection Development Detection Of Abiotic Stimulus Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Protein Tyrosine Kinase Activity Quaternary Ammonium Group Binding Skeletal Muscle Myosin Thick Filament Assembly Cdc42 Protein Signal Transduction Phosphatidylglycerol Binding Myosin Filament Assembly Plasma Membrane Bounded Cell Projection Organization Phosphatidylcholine Transporter Activity Phosphatidylcholine Transfer Activity Response To Mechanical Stimulus Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Macrophage Proliferation Telethonin Binding Skeletal Muscle Thin Filament Assembly Chemorepulsion Of Axon Anterior/posterior Axon Guidance Intercellular Canaliculus Signal Complex Assembly Mammary Gland Duct Morphogenesis Netrin-activated Signaling Pathway Detection Of Stimulus Striated Muscle Thin Filament Regulation Of Cell Junction Assembly Substrate-dependent Cell Migration, Cell Extension Phosphatidylinositol Transfer Activity JUN Kinase Binding Actin Cytoskeleton Protein Kinase A Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Motor Neuron Migration Cytoplasm Vascular Endothelial Cell Response To Fluid Shear Stress Muscle Alpha-actinin Binding	Anterior/posterior Axon Guidance Neuron Projection Guidance Axon Guidance Netrin Receptor Activity Neuron Projection Development Netrin-activated Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Modulation Of Chemical Synaptic Transmission Netrin Receptor Activity Involved In Chemorepulsion Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Cell Surface Negative Regulation Of Neuron Projection Development Growth Cone Neuron Migration Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Neuron Projection Membrane Negative Regulation Of Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Activity Plasma Membrane Cell Death Apoptotic Process Programmed Cell Death Dorsal Root Ganglion Development Relaxation Of Vascular Associated Smooth Muscle Chemorepulsion Of Axon Positive Regulation Of CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Dendrite Development Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Regulation Of CGMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Collateral Sprouting Co-receptor Binding Negative Regulation Of Axon Regeneration BMP Receptor Binding Negative Regulation Of Neuron Projection Regeneration Trans-synaptic Signaling, Modulating Synaptic Transmission Neuron Projection Positive Regulation Of Mast Cell Degranulation Plasma Membrane Protein Complex Ganglion Development Secretion By Cell Positive Regulation Of Adenylate Cyclase Activity
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