NEO1 and NTN1

Number of citations of the paper that reports this interaction (PMID 8861902)
146

Data Source:
HPRD (in vitro, in vivo)

		NEO1	NTN1
Gene Name		neogenin 1	netrin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Basement Membrane Cytoplasm
	Molecular Function	Receptor Activity Cadherin Binding	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cell Adhesion Axon Guidance Myoblast Fusion Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Iron Ion Homeostasis	Neuron Migration Apoptotic Process Axon Guidance Positive Regulation Of Cell Proliferation Single Organismal Cell-cell Adhesion Regulation Of Cell Migration Negative Regulation Of Axon Extension Anterior/posterior Axon Guidance Establishment Of Nucleus Localization Inner Ear Morphogenesis Positive Regulation Of Axon Extension Mammary Gland Duct Morphogenesis
Pathways		CDO in myogenesis Axon guidance Myogenesis Netrin-1 signaling	DSCAM interactions Axon guidance Role of second messengers in netrin-1 signaling DCC mediated attractive signaling Netrin mediated repulsion signals Netrin-1 signaling
Drugs
Diseases
GWAS			Breast cancer (prognosis) ( 23319801)
Protein-Protein Interactions		4 interactors: NTN1 NTN3 PITPNA PTK2	5 interactors: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		4756	9423
HPRD ID		03549	03368
Ensembl ID		ENSG00000067141	ENSG00000065320
Uniprot IDs		Q59FP8 Q92859	O95631
PDB IDs		1X5F 1X5G 1X5H 1X5I 1X5J 1X5K 3P4L
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Nucleus Localization Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nucleus Localization Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Negative Regulation Of Axonogenesis Cell Development Response To External Stimulus Negative Regulation Of Developmental Growth Negative Regulation Of Cell Morphogenesis Involved In Differentiation Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Projection Organization Regulation Of Axonogenesis Neuron Migration Negative Regulation Of Neuron Differentiation Cell Differentiation Negative Regulation Of Growth Netrin-activated Signaling Pathway Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Anterior/posterior Axon Guidance Negative Regulation Of Synapse Assembly System Development Establishment Of Organelle Localization Negative Regulation Of Cell Development Regulation Of Cell Differentiation Signal Complex Assembly Regulation Of Neuron Projection Development Multicellular Organismal Development Organelle Localization Anatomical Structure Development Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization	Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Response To External Stimulus Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Development Positive Regulation Of Cell Death Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Nervous System Development Anatomical Structure Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Apoptotic Process Programmed Cell Death Dorsal/ventral Axon Guidance Cell Death Death Negative Regulation Of Collateral Sprouting Positive Regulation Of Chronic Inflammatory Response Relaxation Of Vascular Smooth Muscle Cell Differentiation Apoptotic Signaling Pathway Relaxation Of Smooth Muscle Regulation Of Apoptotic Process Positive Regulation Of Guanylate Cyclase Activity Regulation Of Cell Death Positive Regulation Of Mast Cell Degranulation Regulation Of Chronic Inflammatory Response Adenosine Receptor Signaling Pathway Positive Regulation Of Mast Cell Activation Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Dendrite Development Positive Regulation Of MAPK Cascade
Tagcloud ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine orbitrap podxl s100a8 secretome serpini1 silac silico sostdc1 spectrometer tnfsf9 tumorigenic velos zg16b	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine orbitrap podxl s100a8 secretome serpini1 silac silico sostdc1 spectrometer tnfsf9 tumorigenic velos zg16b	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?